High-grade trichoblastic carcinosarcoma

The American Journal of Dermatopathology
Dmitry V KazakovEduardo Calonje

Abstract

A case of low-grade trichoblastic carcinosarcoma was reported in 2004. Here we present the second case of this tumor, which, in contrast to the original example, may be classified as a high-grade neoplasm. A 92-year-old man presented with an ulcerated lesion on the left ear. The tumor was excised, and the patient had no evidence of recurrence or metastasis 6 years after surgery. Microscopically, the neoplasm demonstrated a fenestrated growth pattern with a slightly myxoid matrix in the background. Two clear components were identified: the first component was clearly epithelial with formation of small round nests, lobules, delicate strands, and small cribriform structures of basaloid cells with some degree of peripheral palisading, nuclear atypia, focal nuclear crowding, and frequent mitotic figures including abnormal forms. Each epithelial aggregation was invariably surrounded by one to three rows of cells with oval to round nuclei, which appeared very similar to specific trichogenic stroma seen in anagen follicles or in trichoblastomas; however, these stromal cells manifested atypical mitoses and cellular pleomorphism. The epithelial and stromal units frequently formed structures identical to follicular papillae associated wit...Continue Reading

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Citations

Aug 17, 2010·The American Journal of Dermatopathology·Dmitry V KazakovMichal Michal
May 24, 2011·Applied Immunohistochemistry & Molecular Morphology : AIMM·Angel Fernandez-Flores
Aug 16, 2014·Der Pathologe·T Mentzel, A Rütten
Aug 13, 2015·Journal of Cutaneous Pathology·Sui Wing Winney Chu, Asok Biswas
Oct 13, 2016·Journal of Cutaneous Pathology·Joshua J ClarkDavid A Wada
Jun 17, 2016·The American Journal of Dermatopathology·Rafael Parra-MedinaSamuel D Morales
Apr 4, 2017·The American Journal of Surgical Pathology·Liubov KyrpychovaDmitry V Kazakov
Jan 8, 2019·Archives of Craniofacial Surgery·Joon Seok LeeKang Young Choi
Dec 18, 2013·The American Journal of Dermatopathology·Cornelia S L MüllerThomas Vogt
Jun 23, 2018·The American Journal of Dermatopathology·Ilona OkhremchukJean-Jacques Morand
Apr 9, 2013·The American Journal of Dermatopathology·Ksenya V ShelekhovaDmitry V Kazakov
Apr 5, 2014·The American Journal of Dermatopathology·Nathan T HarveyBenjamin A Wood
May 6, 2015·The American Journal of Dermatopathology·Mary D LeDavid S Cassarino
Nov 16, 2019·Journal of Cutaneous Pathology·Caroline I M UnderwoodRami N Al-Rohil

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