PMID: 11926644Apr 3, 2002Paper

High-grade vulval intraepithelial neoplasia (VIN 3): a retrospective analysis of patient characteristics, management, outcome and relationship to squamous cell carcinoma of the vulva 1989-1999

The Australian & New Zealand Journal of Obstetrics & Gynaecology
Peter SykesFrank A Frizelle

Abstract

To determine patient and disease characteristics, treatment patterns and long-term outcomes, in order to help direct management of patients with VIN 3, to examine the risk of development of cancer following a diagnosis of VIN 3 and the risk of recurrent disease requiring multiple treatment episodes, and to review patients with vulval cancer, in order to establish the relative prevalence of VIN 3 related vulval cancers. Retrospective chart review of 65 consecutive patients diagnosed with VIN 3 between 1989 and 1999. All patients diagnosed with VIN 3 at Christchurch Womens' Hospital (1 January 1989 to 31 December 1999) and Dunedin Public Hospital (1 January 1990 to 31 December 1999). Age at diagnosis, symptoms, medical history disease characteristics, treatment, outcome and follow-up. The median age at diagnosis was 38 years. Smokers were younger than non-smokers. Two-thirds had associated dysplasia of the lower genital tract, 43% had high-grade lesions. Seventy-nine per cent were symptomatic for a median of 9.5 months. All had macroscopically visible disease. Colposcopy and histology diagnoses correlated in 72% of cases. Treatment by local excision was undertaken in 84% of cases of which 65% had involved margins. Fifty-one per c...Continue Reading

References

Oct 1, 1995·British Journal of Obstetrics and Gynaecology·R W Jones
Jan 1, 1995·Gynecologic Oncology·R H Kaufman
Jan 1, 1996·Obstetrics and Gynecology·C L TrimbleR J Kurman
May 1, 1996·British Journal of Obstetrics and Gynaecology·J J HerodD M Luesley

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Citations

Jan 9, 2014·Journal of Clinical Pathology·M Carolina Reyes, Kumarasen Cooper
Nov 30, 2012·Histopathology·Marta Del PinoJaume Ordi
May 23, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sonia Ait MenguelletJean-Louis Leroy
Sep 6, 2005·Gynécologie, obstétrique & fertilité·P DeruelleJ-L Leroy
Oct 9, 2003·American Journal of Obstetrics and Gynecology·Stephen K Tyring
Dec 14, 2019·Techniques in Coloproctology·T ChittleboroughFrank Frizelle
Jan 8, 2011·Journal of Evaluation in Clinical Practice·Annemie VlayenNeree Claes
Jun 11, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sadie E F JonesAmanda J Tristram
Sep 19, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Basia M MichalskiM Laurin Council

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