High GRP78 levels in Covid-19 infection: A case-control study

Life Sciences
Ramazan SabirliÖzgür Kurt

Abstract

Covid-19 infection was declared a global pandemic by WHO on March 11, 2020. GRP78 protein is known to be involved in the intrusion of numerous viruses. Our current study tries to provide some insight into the variation of GRP78 protein levels in patients with Covid-19 (-) pneumonia, Covid-19 (+) pneumonia, and CT negative Covid-19 infection in comparison to the normal population through a larger number of cases. 42 patients who have Covid-19 (-) pneumonia; 72 patients who have Covid-19 infection (30 pneumonia,42 CT negative patients) and 30 patient who have no known diseases (control group) have included in the study after the clinical and radiological evaluation. Serum GRP78 levels of the subjects were measured through a commercially available enzyme-linked immunosorbent assay (ELISA) kit. The GRP78 level was found to be significantly higher in the Covid-19 infection group than both Covid-19 (-) pneumonia and control group (p = 0.031 and p = 0.0001, respectively).No significant difference was evident between Covid-19 (-) pneumonia, Covid-19 (+) pneumonia and CT negative Covid 19 infection groups with respect to GRP78 levels (p = 0.09). In addition, the GRP78 levels were significantly higher in the Covid-19 (-) pneumonia group ...Continue Reading

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Citations

May 21, 2021·Frontiers in Pharmacology·Akash SaggamBhushan Patwardhan
Jun 23, 2021·Journal of Maxillofacial and Oral Surgery·Anson JoseSunanda Roychoudhury
Aug 17, 2021·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Bharti SolankiNeha Shakrawal
Aug 27, 2021·Journal of Fungi·Hariprasath PrakashShivaprakash Mandya Rudramurthy
Oct 9, 2021·Mycopathologia·Nata Pratama Hardjo Lugito, Cucunawangsih Cucunawangsih
Aug 23, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shivakumar NarayananJohn W Baddley
Nov 18, 2021·Clinical Microbiology Reviews·Fabián SalazarAdilia Warris

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Methods Mentioned

BETA
PCR
Enzyme-Linked Immunosorbent Assay

Software Mentioned

SPSS

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