High Helicobacter pylori Bacterial Load and Low Cytokine Expression Levels Are Associated with Nodular Gastropathy

Digestive Diseases and Sciences
Rodrigo Mansilla-VivarAlberto Espino

Abstract

Nodular gastropathy (NG) is an inflammatory condition of the gastric mucosa characterized by the endoscopic detection of multiple millimeter protrusions. A strong association between NG and Helicobacter pylori and a possible role of NG as a risk factor for undifferentiated gastric cancer have been described. The aim of this study was to characterize the pathogenic and inflammatory profile of patients with NG. Adult patients referred for upper gastrointestinal endoscopy were prospectively enrolled in this study. H. pylori infection status was determined by rapid urease test. Biopsies were stained with hematoxylin-eosin. Sydney and OLGA scores were used to assess gastritis characteristics and gastric cancer risk. PCR analysis was performed to determine bacterial load and virulence factors CagA (and its EPIYA motifs) and VacA alleles. Finally, gastric mucosa cytokine gene expression (IL-8, IL-1β, and TNF-α) was determined by real-time RT-PCR. Forty-eight patients, mean age of 36 years, were recruited. All NG patients were infected by H. pylori. OLGA score was similar in both groups (NG patients and non-NG patients). NG patients had higher bacterial load in the gastric corpus (p = 0.01) and significantly less pro-inflammatory cytok...Continue Reading

References

Sep 25, 2001·Journal of Pediatric Gastroenterology and Nutrition·E GuiraldesP Harris
May 30, 2003·Digestive Diseases and Sciences·Masaki MiyamotoKazuaki Chayama
Jul 19, 2006·Clinical Microbiology Reviews·Johannes G KustersErnst J Kuipers
Apr 10, 2007·Digestive Diseases and Sciences·Ming-Jen ChenShou-Chuan Shih
Apr 21, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Mustafa AkcamHikmet Cig
Nov 29, 2011·Journal of Digestive Diseases·Ryo NakashimaNaomi Uemura
Feb 26, 2013·Journal of Gastroenterology and Hepatology·Shinji KitamuraTetsuji Takayama
Mar 20, 2016·Revista de gastroenterología de México·C R MejiaL Huiza-Espinoza
Mar 24, 2018·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Young Jung KimHye Seung Han

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