Abstract
Ewing sarcoma (ES) and extraosseous ES/primitive neuroectodermal tumors (PNET) share histopathologic features of the ES family of tumors (ESFT). The authors report on their results from a regimen of ifosfamide, carboplatin, and etoposide (ICE) with cyclophosphamide, doxorubicin, and vincristine (CAV) dose intensification in patients with high-risk ESFT. Since 1990, patients with ESFT and with 1 or more of the following risk factors were reviewed: tumor volume > 200 mL, tumor site with a poor prognosis, and pulmonary and/or bone marrow metastases. Thirty-six patients with ESFT who were involved in the study were divided into 2 arms of 18 patients each. One group received treatment with various regimens, and the other group received treatment with ICE plus CAV. The disease was brought under control more rapidly in the latter patients, for whom surgery was more easily feasible, and up to 90% of patients achieved a major response, with an estimated 3-year overall survival rate of 67% +/- 12%. The current results showed that ICE plus CAV was tolerated well and was effective in the studied subset of tumors, indicating that dose intensification correlates with better disease control, a high percentage of necrosis, and conservative sur...Continue Reading
References
Jun 1, 1991·Cancer·J DunstH Jürgens
Sep 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E O BurgertP Thomas
Nov 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S MiserE Glatstein
Jul 1, 1988·International Journal of Radiation Oncology, Biology, Physics·S L SailerH D Suit
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·V GöbelU Göbel
Nov 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B H KushnerG Heller
Aug 1, 1995·Journal of Pediatric Hematology/oncology·F H KungS Toledano
Sep 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S P ScullyM C Gebhardt
Aug 4, 1994·The New England Journal of Medicine·O DelattreT J Triche
Mar 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K K FieldsG J Elfenbein
Sep 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P PicciP Ruggieri
Jan 1, 1993·The American Journal of Surgical Pathology·L P Dehner
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N M MarinaW Meyer
Mar 1, 1993·Cancer·F H KungB Golembe
Mar 1, 1996·Medical and Pediatric Oncology·C SandovalC B Pratt
Aug 15, 1996·Cancer·T OzakiW Winkelmann
Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R B RaneyH M Maurer
Apr 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P PicciF Bertoni
May 29, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M PaulussenH Jürgens
Sep 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M PaulussenH Jürgens
Aug 3, 1999·Cancer·P RositoG Paolucci
Apr 29, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I ElomaaT A Alvegård
May 8, 2000·Medical and Pediatric Oncology·D HawkinsJ Sanders
Aug 30, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S J CotterillA W Craft
Jan 6, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S BurdachU Go el
Feb 24, 2001·Journal of Pediatric Hematology/oncology·M S CairoG H Reaman
Jul 4, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C R PinkertonT Philip
Sep 25, 2001·Medical and Pediatric Oncology·R D JenkinH P Schultz
May 9, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A M Abu-GhoshM S Cairo
Sep 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E Anders KolbPaul A Meyers
Oct 27, 2004·Pediatric Blood & Cancer·Patrick Van WinkleMitchell S Cairo
Citations
Jan 26, 2010·Bone Marrow Transplantation·I IlariR Cozza
Jul 31, 2013·Journal of Pediatric Hematology/oncology·Antonino TrizzinoPaolo D'Angelo
Feb 6, 2013·PloS One·Maria Antonietta De IorisRoberto Luksch
Feb 25, 2014·Journal of Translational Medicine·Maria Debora De PasqualeRenata Boldrini
Jul 21, 2012·Journal of Pediatric Surgery·Alessandro CrocoliFrancesco Morini
Apr 29, 2015·Pediatric Blood & Cancer·Algemir L BrunettoUNKNOWN Brazilian Collaborative On behalf of the Brazilian Collaborative Study Group of Ewing Family of Tumors EWING1 and the Brazil
Jun 1, 2014·BBA Clinical·Federica SalettaJennifer A Byrne
Jul 31, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Massimo BergerRoberto Luksch
Nov 14, 2015·World Journal of Clinical Pediatrics·Surasak Sangkhathat
Aug 5, 2009·Internal Medicine·Tadanobu NagayaKiyoshi Kitano
May 25, 2020·The Breast Journal·Kyrillus S ShohdyLoay Kassem
Nov 1, 2012·Thoracic Cancer·Shinya TaneMasahiro Yoshimura
Oct 17, 2020·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Saipavan AnneGopal Palanki
Feb 25, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Alberto RighiAngelo Paolo Dei Tos