High HIV prevalence in an early cohort of hospital admissions with COVID-19 in Cape Town, South Africa

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
A ParkerJ J Taljaard

Abstract

South Africa (SA) has a high prevalence of HIV and tuberculosis. Cape Town was the SA metropole most affected in the early stages of the COVID-19 pandemic. Early observational data from Africa may provide valuable insight into what can be expected as the pandemic expands across the continent. To describe the prevalence, clinical features, comorbidities and outcome of an early cohort of HIV-positive and HIV-negative patients admitted with COVID-19. This was a descriptive observational study of an early cohort of adults with COVID-19 pneumonia admitted from 25 March to 11 May 2020. Of 116 patients (mean age 48 years, 61% female) admitted, 24 were HIV-positive (21%). The most common symptoms reported were cough (n=88; 73%), shortness of breath (n=78; 69%), fever (n=67; 59%), myalgia (n=29; 25%) and chest pain (n=22; 20%). The most common comorbidities were hypertension (n=46; 41%), diabetes mellitus (n=43; 38%), obesity (n=32; 28%) and HIV (n=24; 21%). Mortality was associated with older age (mean (standard deviation) 55 (12) years v. 46 (14) years; p<0.01); the presence of hypertension or hypertension along with diabetes and/or obesity; lower partial pressure of arterial oxygen to fraction of inspired oxygen ratio; and higher ...Continue Reading

Citations

Jan 28, 2021·AIDS Research and Human Retroviruses·Timotius Ivan HariyantoAndree Kurniawan
Feb 19, 2021·BMJ : British Medical Journal·Lawrence MwananyandaDonald Thea
Mar 10, 2021·Journal of Racial and Ethnic Health Disparities·Gail Denise HughesThandi Rose Puoane
Apr 4, 2021·International Journal of Environmental Research and Public Health·Kai Wei LeeMunn Sann Lye
Oct 4, 2020·The American Journal of Tropical Medicine and Hygiene·Jean B NachegaJean-Marie Kayembe
Mar 21, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hiluf Ebuy AbrahaDawit Wolday
May 4, 2021·Southern African Journal of HIV Medicine·Timotius I HariyantoAndree Kurniawan
Jun 4, 2021·MMWR. Morbidity and Mortality Weekly Report·Duncan ChandaLloyd B Mulenga
May 26, 2021·Respiration; International Review of Thoracic Diseases·Coenraad F N KoegelenbergChristoph Lange

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