High Hydrostatic Pressure Extract of Red Ginseng Attenuates Inflammation in Rats with High-fat Diet Induced Obesity

Preventive Nutrition and Food Science
Sunyoon JungYangha Kim

Abstract

Chronic low-grade inflammation is associated with obesity. This study investigated effect of high hydrostatic pressure extract of red ginseng (HRG) on inflammation in rats with high-fat (HF) diet induced obesity. Male, Sprague-Dawley rats (80~110 g) were randomly divided into two groups, and fed a 45% HF diet (HF) and a 45% HF diet containing 1.5% HRG (HF+HRG) for 14 weeks. At the end of the experiment, the serum leptin level was reduced by the HRG supplementation. The mRNA expression of genes related to adipogenesis including peroxisome proliferator-activated receptor-gamma and adipocyte protein 2 was down-regulated in the white adipose tissue (WAT). The mRNA levels of major inflammatory cytokines such as tumor necrosis factor-α, monocyte chemoattractant protein 1, and interleukin-6 were remarkably down-regulated by the HRG in WAT. These results suggest that HRG might be beneficial in ameliorating the inflammation-associated health complications by suppressing adipogenic and pro-inflammatory gene expression.

References

Oct 14, 2000·Annual Review of Physical Chemistry·R J Hemley
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 9, 2002·Biological & Pharmaceutical Bulletin·Ki-Hyun ParkHwa-Jin Park
Sep 6, 2002·Biochemical Pharmacology·Eric Duplus, Claude Forest
Aug 12, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Alexa T Smolinski, James J Pestka
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Dec 18, 2003·The Journal of Clinical Investigation·Kathryn E Wellen, Gokhan S Hotamisligil
Nov 3, 2004·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T ChristiansenJ M Bruun
Jan 25, 2005·Current Diabetes Reports·Yong-Ho Lee, Richard E Pratley
May 4, 2005·The Journal of Allergy and Clinical Immunology·Giamila Fantuzzi
Apr 8, 2006·Physiological Reviews·Béatrice DesvergneWalter Wahli
Jan 22, 2011·Nature Reviews. Immunology·Noriyuki OuchiKenneth Walsh
Dec 13, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hyunghee LeeMichung Yoon
Jan 19, 2013·Arquivos brasileiros de endocrinologia e metabologia·Gilberto Paz-FilhoJulio Licinio
Jun 1, 2011·Journal of Ginseng Research·Hyun-Jeong KimIn-Seon Lee
Apr 17, 2014·Journal of Ethnopharmacology·Yanyan YangJae Youl Cho

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Citations

Oct 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yoon Hee LeeHocheol Kim
Jun 5, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Hye-Sung ParkMi-Yeon Song
Aug 12, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hanbing LiLinghuan Li

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