High IGFBP2 levels are not only associated with a better metabolic risk profile but also with increased mortality in elderly men

European Journal of Endocrinology
Annewieke W van den BeldSteven W J Lamberts

Abstract

Serum IGF-binding protein 2 (IGFBP2) concentrations are reduced in obese humans and increase after a prolonged period of fasting. We investigated the association between IGFBP2 levels and mortality together with other factors that are related to IGFBP2, including the metabolic syndrome and physical function. A prospective observational study at a clinical research center of 403 independently living elderly men (aged 73-94 years). Mortality was registered during 8.6 years of follow-up. Physical performance score (PPS), grip strength (GS), and bone mineral density (BMD) were measured. The measurements taken a baseline were: IGF1; IGFBP1, -2, and -3; IGF1 bioactivity; triiodothyronine (T(3)); and reverse T(3). Further, BMI, insulin sensitivity, cholesterol, inflammatory markers, and albumin levels were also measured. During the follow-up, 180 men died. Higher PPS, GS, and BMD were independently related to a reduced mortality (hazard ratio (HR)=0.87/point, 95% confidence interval (95% CI)=0.82-0.91, P<0.001; HR=0.96/kp, 95% CI 0.94-0.98, P<0.001; and HR=0.21/(g/cm(2)), 95% CI 0.07-0.61, P<0.01). Higher serum IGFBP2 levels were strongly related to mortality (HR=2.26/(mg/l), 95% CI 1.57-3.27, P<0.001). This was independent of comorbi...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Oct 11, 1991·The Journal of Clinical Endocrinology and Metabolism·D R ClemmonsW H Busby
Jun 1, 1990·The American Journal of Clinical Nutrition·R B MazessJ Hanson
Jan 1, 1986·Metabolism: Clinical and Experimental·A GotfredsenC Christiansen
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J I JonesD R Clemmons
Feb 1, 1995·Endocrine Reviews·J I Jones, D R Clemmons
Jul 1, 1994·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·A HamiltonR Adams
Dec 10, 1999·Diabetes/metabolism Research and Reviews·J FrystykH Orskov
Jun 5, 2002·Trends in Genetics : TIG·Christy S CarterWilliam E Sonntag
Dec 31, 2002·American Journal of Epidemiology·A W van den BeldD E Grobbee
Feb 27, 2003·American Journal of Physiology. Endocrinology and Metabolism·Jian-Wen ChenJan Frystyk
May 30, 2003·European Journal of Endocrinology·Annewieke W van den BeldSteven W J Lamberts
Oct 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Michelangela BarbieriGiuseppe Paolisso
Aug 18, 2006·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A H HealdJ M Gibson
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julie L EisemanMerrill J Egorin
Apr 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Michael P BrugtsJoseph A M J L Janssen
Apr 8, 2009·Trends in Endocrinology and Metabolism : TEM·Stephen B Wheatcroft, Mark T Kearney
May 30, 2009·Endocrine Reviews·Sherryline Jogie-BrahimYoungman Oh
Jun 30, 2009·Journal of the American Geriatrics Society·Donglei HuUNKNOWN Health, Aging, and Body Composition Study
Oct 23, 2009·The Journal of Clinical Endocrinology and Metabolism·Ayman M ArafatAndreas F H Pfeiffer
Sep 11, 2010·BMJ : British Medical Journal·Rachel CooperUNKNOWN FALCon and HALCyon Study Teams
Aug 17, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Raj S PadwalArya M Sharma
Nov 23, 2011·Metabolic Syndrome and Related Disorders·Abayomi O Akanji, Robert J Smith

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Citations

Nov 26, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Elisa WirthgenAndreas Hoeflich
Mar 17, 2015·Frontiers in Endocrinology·Adam Pickard, Dennis J McCance
Nov 7, 2016·Clinical Neurology and Neurosurgery·Xing-Wang ZhouQing Mao
Mar 23, 2018·Journal of Molecular Endocrinology·David R Clemmons
Jun 14, 2020·International Journal of Molecular Sciences·Pia FahlbuschJorg Kotzka
Jun 20, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Marc-André NolinFrédéric Picard
Sep 25, 2017·Scientific Reports·Elisa WirthgenAndreas Hoeflich

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