PMID: 9184655Jun 1, 1997Paper

High IL-6 and low IL-10 in the central nervous system are associated with protracted relapsing EAE in DA rats

Journal of Neuropathology and Experimental Neurology
A DiabH Link

Abstract

Experimental autoimmune encephalomyelitis (EAE) is a CD4+ T cell-mediated, inflammatory demyelinating disease of the central nervous system (CNS) that serves as a model for multiple sclerosis (MS). The mechanisms behind differences in clinical course of EAE in different rat strains have not been defined. We induced acute EAE in Lewis rats and protracted relapsing EAE (PR-EAE) in DA rats and examined mRNA expression of IL-1 beta, IL-6, IL-10, IL-12, and TNF-beta in brain tissue sections, cerebrospinal fluid (CSF) cells, and lymph node cells. IL-1 beta, IL-12 and TNF-beta mRNA expression in brain tissue sections appeared early and peaked at the height of clinical signs in both acute and PR-EAE, consistent with a disease-promoting role for these cytokines. High levels of IL-6 mRNA-expressing cells were present in CNS and lymph node cells in PR-EAE, while almost absent in acute EAE. In contrast, IL-10 was very low in PR-EAE but strongly expressed in acute EAE, in particular during clinical recovery. Regulatory changes of IL-6 and IL-10 both systemically and within the CNS, but with temporal differences between compartments, seem pivotal for development of PR-EAE in DA rats. These findings could have relevance for pathogenesis and t...Continue Reading

Citations

Jun 9, 1999·Annals of Neurology·C L Karp
Jul 20, 2000·Journal of Neuroimmunology·N TanumaY Matsumoto
Apr 8, 1999·Clinical and Experimental Immunology·S InogésA Sánchez-Ibarrola
Feb 13, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Staley A Brod
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S A Brod
Jul 11, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Y OkudaT Yanagihara
Jun 11, 2014·PloS One·Sam Joshva Baskar JesudasanIan R Winship
Aug 6, 2002·Journal of Neuroimmunology·Kenichi SakuraiGene M Shearer
Dec 16, 1998·Journal of the Neurological Sciences·J ZhuG Hedlund
May 21, 2013·Archives of Medical Research·Mandana Mohyeddin BonabBehrooz Nikbin
Jul 18, 2008·Journal of Neuroimmunology·Sreeram V RamagopalanGeorge C Ebers

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