High-impact poly(L/D-lactide) for fracture fixation: in vitro degradation and animal pilot study

Biomaterials
J TamsA J Pennings

Abstract

The impact strength of amorphous lactide copolymers can be significantly improved by blending with biodegradable rubbers. Rubber toughening of amorphous poly(85L/15D -lactide) with the copolymer poly (50/50-trimethylenecarbonate-co-epsilon-caprolactone) results in a high-impact polymer (PDLLA/P(TMC-CL)). In vitro, the PDLLA/P(TMC-CL) blend retained its tensile and impact strength for a long period of time. Up to 45 weeks, the amount of water absorbed by the blend remained very low and no significant mass loss was observed. To test the suitability for fracture fixation, in a dog study mandibular fractures were fixated with PDLLA/P(TMC-CL) bone plates and screws. Bone healing was uneventful without premature failure of the implants. Although long-term degradation studies have to be carried out, PDLLA/P(TMC-CL) seems to be promising for application in fracture fixation.

References

Mar 1, 1990·Biomaterials·Y Cha, C G Pitt
Dec 1, 1989·International Journal of Oral and Maxillofacial Surgery·R R BosA B Verwey
Dec 1, 1989·The British Journal of Oral & Maxillofacial Surgery·R R BosH W Jansen
Apr 1, 1989·The British Journal of Oral & Maxillofacial Surgery·F R RozemaA J Pennings
Feb 1, 1986·International Journal of Oral and Maxillofacial Surgery·H H HorchH E Schaefer
Sep 1, 1987·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·R R BosJ W Leenslag
Jun 1, 1993·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·E J BergsmaW C de Bruijn

❮ Previous
Next ❯

Citations

May 11, 2005·Journal of Materials Science. Materials in Medicine·P V Peplow, G J Dias
Sep 19, 2000·Tissue Engineering·F W Cordewener, J P Schmitz
Jun 23, 2001·Plastic and Reconstructive Surgery·N AshammakhiT Waris
Dec 22, 2005·Journal of Biomaterials Science. Polymer Edition·Suleyman CoskunVasif Hasirci
Jul 3, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Rafał Petrus, Piotr Sobota
Apr 16, 2011·Journal of Biomedical Materials Research. Part a·Markus LindnerHorst Fischer
Aug 7, 1999·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J TamsR R Bos
Feb 1, 1996·International Journal of Oral and Maxillofacial Surgery·J TamsA Vermey
Aug 15, 2003·Journal of Biomedical Materials Research. Part a·J Carson MeredithEric J Amis
Jul 1, 1997·The Hastings Center Report·C E Schneider
Jul 6, 2000·Journal of Biomedical Materials Research·A K BurkothK S Anseth
Jul 28, 2011·Ear, Nose, & Throat Journal·Larry Lundy, Selmin Karatayli-Ozgursoy
Nov 16, 2011·Journal of Applied Biomechanics·Cameron CoatesMark Jenkins
Jan 2, 2010·The Journal of Bone and Joint Surgery. British Volume·P VäänänenJ Pajamäki
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raasti NaseemKenny Dalgarno
Jul 5, 2016·ACS Sustainable Chemistry & Engineering·Veluska AriasAnn-Christine Albertsson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioremediation (ASM)

Bioremediation is the treatment and removal of harmful pollutants or contaminants through the use of microorganisms. Discover the latest research here.