High in-hospital mortality of intensive care patients with nucleated red blood cells in blood

Clinical Chemistry and Laboratory Medicine : CCLM
A StachonMichael Krieg

Abstract

The detection of nucleated red blood cells (NRBCs) in blood of patients suffering from a variety of severe diseases is known to be highly associated with increased mortality. Blood analyzers to routinely measure NRBC concentrations are now available. However, the diagnostic and prognostic significance of this parameter for intensive care patients has not been evaluated. Using a Sysmex XE-2100 analyzer, NRBC concentrations were determined in blood samples from 421 patients treated in intensive care units (general and accident surgery, cardiothoracic surgery, and internal medicine) of a university hospital. NRBCs were found at least once in 19.2% of all patients. The mortality of NRBC-positive patients (n=81) was 42.0% (n=34); this was significantly higher (p<0.001) than the mortality of NRBC-negative patients (5.9%, n=340). The NRBC concentration was 115+/-4x10(6)/l (median 40x10(6)/l; range 20-2930x10(6)/l) at initial detection of NRBCs in the blood. Mortality increased with increasing NRBC concentration and increasing frequency of occurrence. With regard to in-hospital mortality, NRBCs in blood showed sensitivity and specificity of 63.0% and 87.2%, respectively. The detection of NRBCs is highly predictive of death, the odds ra...Continue Reading

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Citations

Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Dan T A EisenbergChristopher W Kuzawa
May 9, 2009·Journal of Veterinary Internal Medicine·I ArochY Bruchim
Jun 7, 2007·Critical Care : the Official Journal of the Critical Care Forum·Axel StachonMichael Krieg
Aug 2, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Axel StachonMichael Krieg
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