High incidence of acute kidney injury during chemotherapy for childhood acute myeloid leukemia

Pediatric Blood & Cancer
Liezl Du PlessisCherry Mammen

Abstract

Childhood acute myeloid leukemia (AML) is a rare and heterogeneous disease. Pediatric data on the epidemiology of acute kidney injury (AKI) in AML are limited. We report on the incidence of AKI in childhood AML and the risk factors associated with AKI episodes. A retrospective cohort of 53 patients (≤18 years), with de novo AML, receiving chemotherapy over a 10-year period. All serum creatinine (SCr) levels during therapy-related hospitalizations were assessed to stage AKI episodes as per Kidney Disease: Improving Global Outcomes criteria. Severe AKI was defined as AKI stages 2 or 3 and urine output criteria were not used. AKI risk factors were assessed independently in both cycle 1 alone and combining all chemotherapy cycles. AKI developed in 34 patients (64%) with multiple AKI episodes in 10 patients (46 total episodes). Twenty-four severe AKI episodes occurred in 23 patients (43.4%) with a mean duration of 26.1 days (SD 7.3). In cycle 1, hyperleukocytosis was not predictive of AKI, but severe sepsis was an independent risk factor of severe AKI (odds ratio [OR]: 13.4; 95% CI 1.9-94.9). With cycles combined, all subjects with AKI had severe sepsis and older age (≥10 years) was associated with severe AKI (OR: 20.8; 95% CI 3.8-1...Continue Reading

References

Mar 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R A ZagerE D Thomas
Jan 1, 1989·Kidney International·H N Georgaki-AngelakiG B Haycock
Jan 1, 1995·American Journal of Nephrology·E GrussJ M Fernandez-Rañada
Jun 5, 2001·Pediatrics·S L GoldsteinR Sachdeva
Feb 19, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Walter T HughesLowell S Young
Apr 30, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ludwig PatzerJoachim Misselwitz
Dec 22, 2004·Kidney International·Sangeeta R HingoraniGeorge B McDonald
Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brahm GoldsteinUNKNOWN International Consensus Conference on Pediatric Sepsis
Feb 8, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shirley Hui-StickleStuart L Goldstein
Aug 18, 2005·JAMA : the Journal of the American Medical Association·Shigehiko UchinoUNKNOWN Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators
Dec 24, 2005·Kidney International·D J AskenaziS L Goldstein
Jan 21, 2006·Critical Care Medicine·Jean-Louis VincentUNKNOWN Sepsis Occurrence in Acutely Ill Patients Investigators
Mar 31, 2007·Kidney International·A Akcan-ArikanS L Goldstein
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Sean M BagshawUNKNOWN Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators
Jan 10, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mirja WedekinLars Pape
Apr 11, 2008·Critical Care Medicine·Neesh Pannu, Mitra K Nadim
Apr 12, 2008·Critical Care : the Official Journal of the Critical Care Forum·Sean M BagshawUNKNOWN ANZICS Database Management Committee
Jul 2, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael ZappitelliStuart L Goldstein
Jul 24, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Amy StaplesJohn Brandt
Aug 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brigitte C WidemannPeter C Adamson
Dec 15, 2010·Seminars in Nephrology·Mark A Perazella, Gilbert W Moeckel
Dec 15, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jonas AbrahamssonHenrik Hasle
Mar 9, 2011·Bone Marrow Transplantation·J A Lopes, S Jorge
Sep 10, 2011·British Journal of Haematology·Brenda E S GibsonUNKNOWN United Kingdom Childhood Leukaemia Working Group and the Dutch Childhood Oncology Group
Sep 29, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marianne ViaudJérôme Harambat
Dec 31, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cherry MammenDouglas G Matsell
Jun 8, 2012·Cancer·Jeffrey E RubnitzHiroto Inaba
Aug 11, 2012·Blood·Ursula CreutzigUNKNOWN AML Committee of the International BFM Study Group
Sep 8, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David DixLillian Sung
Jul 9, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Scott M SutherlandXuefeng B Ling
Aug 1, 2014·Intensive Care Medicine·David T SelewskiDebbie S Gipson
Feb 5, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Scott M SutherlandStuart L Goldstein
Mar 22, 2015·Seminars in Nephrology·Rashid AlobaidiSean M Bagshaw
May 13, 2015·Pediatric Transplantation·Madeleine S DidsburySean E Kennedy
Dec 29, 2015·Critical Care : the Official Journal of the Critical Care Forum·Marlies OstermannLui G Forni
Apr 2, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sarah J KizilbashAngela R Smith
Aug 9, 2016·The Oncologist·Scott C HowardR Donald Harvey
Aug 12, 2016·Critical Care Medicine·Julie C FitzgeraldUNKNOWN Sepsis PRevalence, OUtcomes, and Therapies Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators Netw
Dec 14, 2016·The New England Journal of Medicine·Ahmad KaddourahUNKNOWN AWARE Investigators

❮ Previous
Next ❯

Citations

Mar 16, 2019·The Journal of Pediatrics·Peong Gang ParkHee Gyung Kang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Related Papers

Clinical Journal of the American Society of Nephrology : CJASN
Erin HesseyMichael Zappitelli
Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Youn-Jung KimWon Young Kim
© 2022 Meta ULC. All rights reserved