High incidence of chemotherapy-induced acral erythema in female patients with non-Hodgkin's lymphoma treated with the VACOP-B regimen

Leukemia & Lymphoma
H OgawaT Kishimoto

Abstract

Seven patients, all females out of 29 with non-Hodgkin's lymphoma (NHL) (16 males and 13 females) treated with the VACOP-B regimen utilizing granulocyte-colony-stimulating factor (G-CSF) support developed chemotherapy-induced acral erythema (CAE). In contrast, none of 32 patients with NHL who were treated with CHOP, MACOP-B, or biweekly CHOP regimens without G-CSF developed CAE. Total dose intensities of VACOP-B regimen were higher than those of the three other regimens. However, no significant difference in dose intensities of each drug in the patients treated with the VACOP-B regimen was found between male and female patients and between female patients with or without CAE. The cause of the high incidence of CAE (7/13) in the female patients treated with VACOP-B regimen remains unknown. However, female sex hormones may increase susceptibility to CAE. Since the occurrence of CAE interrupts intensive chemotherapy and reduces the cure rate, high risk patients for CAE should be carefully monitored for early symptoms and signs of CAE and should be treated early and appropriately.

References

Jan 1, 1991·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S E O'ReillyJ M Connors
Dec 1, 1991·British Journal of Obstetrics and Gynaecology·D FraserR J King
Mar 1, 1991·Journal of the American Academy of Dermatology·B R Baack, W H Burgdorf
May 1, 1985·Annals of Internal Medicine·P Klimo, J M Connors
Dec 1, 1986·Archives of Dermatology·G J Cox, D B Robertson
Sep 1, 1986·Archives of Dermatology·M K CriderM S McHale
Apr 1, 1985·Annals of Internal Medicine·M R BaerS N Wolff
Nov 1, 1985·Annals of Internal Medicine·W G Peters, R Willemze
Apr 1, 1973·Archives of Dermatology·I S CohenR C De Conti
Dec 1, 1984·Annals of Internal Medicine·J J Lokich, C Moore
May 1, 1983·Annals of Internal Medicine·L A DoyleB Chabner
May 1, 1983·Annals of Internal Medicine·F S SilverR C Hartmann
Jul 1, 1982·Annals of Internal Medicine·W H BurgdorfR G Ganick
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·I PortalX Garcia-del-Muro

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Citations

Oct 26, 2007·Pediatric Dermatology·Carly R VarelaRichard J Antaya
Jul 16, 2014·Clinics in Dermatology·James E Song, Robert Sidbury
Apr 5, 2005·Pediatric Hematology and Oncology·Sergey Postovsky, Myriam Weyl Ben Arush
Feb 14, 2006·Seminars in Oncology·Nasir ShahabDonald C Doll
Apr 29, 2005·Journal of the American Academy of Dermatology·Andrew E WerchniakJames G H Dinulos
Jun 16, 2018·Proceedings·Priyanka Jalandhara, Gurjit Kaeley

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