High incidence of common bile duct dilatation in autosomal dominant polycystic kidney disease patients

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
I IshikawaT Yuri

Abstract

Two autosomal dominant kidney disease (ADPKD) patients with cholecystitis or communicating extrahepatic dilatation of the common bile duct accompanied by tiny common bile duct stones prompted us to examine the incidence of gall stone disease and dilatation of the common bile duct in ADPKD patients. Computed tomography scans were examined retrospectively in 55 ADPKD patients and 55 age-, gender-, and duration of dialysis-matched non-ADPKD patients. The incidence of calcium-containing gall stones found on tomography scans was the same: eight of the 55 ADPKD patients and nine of the 55 non-ADPKD patients. However, common bile duct dilatation, defined as measuring more than 7 mm in diameter at the pancreatic head on CT scans, was found more frequently in the ADPKD patients (22 patients; 40.0%) than in the non-ADPKD patients (5 patients; 9.1%) (P = 0.0002). These results suggest that the high incidence of intrapancreatic common bile duct dilatation in ADPKD is a previously undescribed sign of extracellular matrix remodeling in ADPKD.

References

Jul 1, 1990·Mayo Clinic Proceedings·A TelentiR R Hattery
Jan 1, 1990·Radiology·B I ChoiM C Han
Sep 1, 1987·Journal of Computer Assisted Tomography·J FarmanS Glanz
Oct 1, 1971·Annals of Surgery·W P LongmireH E Gordon
Feb 1, 1980·Journal of Computer Assisted Tomography·W D FoleyT L Lawson
Nov 1, 1994·Journal of the American Society of Nephrology : JASN·V E TorresD M Nogorney
Jul 29, 1993·The New England Journal of Medicine·P A Gabow

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Citations

Sep 10, 2002·Journal of Computer Assisted Tomography·Denis KrauséPatrick Hillon
Jan 15, 2019·Journal of Magnetic Resonance Imaging : JMRI·Weiguo ZhangMartin R Prince
Dec 14, 2018·Nature Reviews. Disease Primers·Carsten BergmannVicente E Torres
Feb 28, 2013·Journal of Clinical Gastroenterology·Ha-Na KimJae Hoon Lim
May 4, 2017·Journal of the American Society of Nephrology : JASN·Parminder K JudgeWilliam G Herrington
Nov 9, 2017·Oncotarget·Shih-Ting HuangLong-Bin Jeng
Apr 17, 2007·Lancet·Vicente E TorresYves Pirson
Apr 20, 2021·Clinical Liver Disease·Danielle Brandman
Jun 14, 2019·Mayo Clinic Proceedings. Innovations, Quality & Outcomes·William P MartinMarie C Hogan
Mar 12, 2010·Advances in Chronic Kidney Disease·Yves Pirson

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