Abstract
This study evaluated the relationship between synchronous multiple gastric cancer and other primary malignancies. During 2002-2013, 1094 consecutive surgically treated gastric cancer patients were enrolled. Preoperatively, we performed total colonoscopy and whole-body computed tomography. When malignancies in other organs were suspected, detailed organ-specific examinations were performed. Synchronous multiple gastric cancer occurred in 102 patients (9.3%)which was frequently observed in patients with preoperative other primary malignancies (p < 0.001). Preoperative other primary malignancy was an independent risk factor for synchronous multiple gastric cancer (p = 0.001; hazard ratio: 2.145, 95% confidence interval: 1.354-3.399) and an independent prognostic factor of overall survival in patients undergoing gastrectomy with curative intent (p = 0.021; hazard ratio: 1.481, 95% confidence interval: 1.060-2.070). Thus, patients with preoperative other primary malignancies have a high risk of synchronous multiple gastric cancer. Careful preoperative examination is recommended to improve survival.
References
Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Nov 5, 1997·World Journal of Surgery·K TakeshitaM Endo
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·E MiyoshiK Chayama
Apr 18, 2002·Journal of Clinical Gastroenterology·Mário Dinis-RibeiroRafael Lomba-Viana
Jul 24, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F BorieUNKNOWN French Associations for Surgical Research
Dec 16, 2004·Langenbeck's Archives of Surgery·Young Kyu ParkShin Kon Kim
Feb 5, 2008·The Journal of Surgical Research·Elliot MitmakerMark Trifiro
Mar 22, 2008·The Journal of Urology·Hiroshi HirataRajvir Dahiya
May 3, 2008·Journal of Surgical Oncology·Bang Wool EomKuhn Uk Lee
May 13, 2008·Cancer·Haixia GuanMingzhao Xing
Jun 23, 2010·Surgical Oncology·Jiayuan Peng, Yu Wang
Oct 19, 2011·Journal of Surgical Oncology·Bang Wool EomYoung-Woo Kim
Mar 19, 2013·Annals of Surgical Oncology·Naoki HikiXiaohua Jiang
Aug 24, 2013·BMC Cancer·Chan KimSun Rha
Feb 25, 2014·Annals of Surgical Oncology·Toshiyasu OjimaHiroki Yamaue
May 8, 2014·International Journal of Surgery·Daisuke TakeuchiShinichi Miyagawa
Jan 7, 2015·World Journal of Gastroenterology : WJG·Hans RaskovJacob Rosenberg
Jan 24, 2015·Clinics and Research in Hepatology and Gastroenterology·Sun Ming-ZhongZhu Rong
Nov 2, 2016·Thyroid : Official Journal of the American Thyroid Association·Hyeong Sik AhnJuan P Brito
Jan 21, 2017·Current Problems in Cancer·Minsoo Jung