PMID: 7517699May 1, 1994Paper

High incidence of uterine inversion in mast cell-deficient osteopetrotic mutant mice of mi/mi genotype

Biology of Reproduction
H YokoiK J Mori

Abstract

Mutations at either W or mi (microphthalmia) loci in the mouse can lead to a deficiency in melanocytes and mast cells. In addition, W mutants can be anemic and sterile, whereas mi mice are osteopetrotic because of a monocyte/macrophage/osteoclast defect. Since c-kit receptor tyrosine kinase is the gene product of the W locus and mi mutation has been suggested to affect the transduction of signals from the c-kit and c-fms receptors, we here examined the effect of mi mutation on fertility. Testes and ovaries from mi/mi mice were histologically normal, and the pattern of c-kit protein expression was not different from that of +/+ mice. Homozygous mutant crosses (mi/mi x mi/mi) were fertile, but inversion of the uterus occurred in 86% of the deliveries. In some cases, the placenta was found still attached to the inverted uterus after delivery. Decidual cells were present and expressed c-kit protein normally in the placenta of mi/mi mice. The inversion was also observed in mi/mi females mated to +/+ males. No uterine inversion was noted when +/mi females were crossed with mi/mi or +/mi males, suggesting that the genotype of the mother but not of the father or fetus is important for the pathogenesis. The numbers and body weights of m...Continue Reading

Citations

Feb 13, 2001·Journal of Reproductive Immunology·H TadrosM Mbikay
Jun 1, 1997·The Journal of Obstetrics and Gynaecology Research·S M DaliS Shrestha
Jun 1, 1996·American Journal of Reproductive Immunology : AJRI·M J GuimondB A Croy
Oct 25, 2003·Biochemical and Biophysical Research Communications·Masaru MurakamiMasayuki Funaba

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