PMID: 11917242Mar 28, 2002Paper

High indinavir Cmin is associated with higher toxicity in patients on indinavir-ritonavir 800/100 mg twice-daily regimen

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Caroline SolasBruno Lacarelle

Abstract

We retrospectively evaluated the incidence of side effects and treatment intervention according to indinavir trough concentration in 63 patients taking indinavir-ritonavir 800/100 mg twice daily. Median indinavir trough concentration was 1446 ng/mL at 800/100 mg twice daily associated with 60% of measured toxicity. Among patients with indinavir trough concentration >500 ng/mL, 46 of 49 had a dosage adjustment and 17 have had more than two dosage adjustments. The primary reason for dosage adjustment was toxicity in 69% (43 cases). Renal and cutaneous toxicity were predominant.After dosage adjustment, median indinavir trough concentration was 459 ng/mL, which was associated with 8% of toxicity. Trough concentrations >500 ng/mL were correlated with increased toxicity (p <.05) and more treatment intervention (p =.02). In conclusion, achievement of indinavir trough concentrations <500 ng/mL appears to be safe, and an optimal concentration range for indinavir trough concentration could be 150 to 500 ng/mL for an indinavir-ritonavir twice daily regimen.

References

Jun 5, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·A L JayewardeneJ G Gambertoglio
Nov 13, 1998·Clinical Pharmacokinetics·A HsuR J Bertz
Jul 3, 1999·Pharmacotherapy·E P AcostaC V Fletcher
Apr 25, 2001·British Journal of Clinical Pharmacology·D J BackC Merry

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Citations

Dec 5, 2002·Pharmacoepidemiology and Drug Safety
Sep 28, 2006·Journal of Pharmacokinetics and Pharmacodynamics·Smita A KshirsagarDavide Verotta
Sep 4, 2010·The Journal of Antimicrobial Chemotherapy·Stephanie DominguezChristine Katlama
Jul 28, 2010·Antimicrobial Agents and Chemotherapy·Trevor Van SchooneveldCourtney V Fletcher
Dec 24, 2005·Enfermedades infecciosas y microbiología clínica·Esteve RiberaJosep Mallolas
Mar 7, 2007·The Journal of the Association of Nurses in AIDS Care : JANAC·Michael Sension, Peter J Piliero
May 3, 2007·Expert Opinion on Pharmacotherapy·Mark Boyd
Apr 10, 2007·Therapeutic Drug Monitoring·Fidéline CollinUNKNOWN ANRS CO8 Aproco-Copilote Study Group
Sep 24, 2004·Therapeutic Drug Monitoring·Christopher S AlexanderP Richard Harrigan
Sep 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lawrence S LeeCharles Flexner
May 23, 2007·British Journal of Clinical Pharmacology·Caroline SolasIsabelle Poizot-Martin
Aug 12, 2005·Current Opinion in Oncology·Gary Kalkut
Aug 27, 2005·British Journal of Clinical Pharmacology·Bregt S KappelhoffJos H Beijnen
Oct 29, 2004·Clinical Pharmacokinetics·Bregt S KappelhoffJos H Beijnen
May 27, 2003·Therapeutic Drug Monitoring·Monique M R de MaatJos H Beijnen
Aug 9, 2019·Therapeutic Drug Monitoring·Dario CattaneoUNKNOWN IATDMCT Anti-Infective Committee
Mar 18, 2004·British Journal of Clinical Pharmacology·Caroline SolasBruno Lacarelle
Apr 12, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·James D Scott
Feb 8, 2011·Clinical Pharmacokinetics·Michael N Neely, Natella Y Rakhmanina
Jan 28, 2005·Kidney International·Eric DaugasGary Hill

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