High inflammogenic potential of rare earth oxide nanoparticles: the New Hazardous Entity

Nanotoxicology
Youngju HanWan-Seob Cho

Abstract

Due to the exponential increase in the development and utilization of rare earth oxide nanoparticles (REO NPs) in various fields, the possibility of exposure in humans by inhalation has increased. However, there are little information about hazards of REO NPs and its mechanisms of toxicity. In this study, we evaluated the acute pulmonary inflammation using 10 REO NPs (Dy2O3, Er2O3, Eu2O3, Gd2O3 La2O3, Nd2O3, Pr6O11, Sm2O3, Tb4O7, and Y2O3) and four well-known toxic particles (CuO, NiO, ZnO, and DQ12). Minimum three doses per NP were instilled into the lungs of female Wistar rats at surface area dose metric and lung inflammation was evaluated at 24 h post-instillation by bronchoalveolar lavage fluid (BALF) analysis and histopathological observation. All types of REO NPs showed common pathological changes including mild to moderate infiltration of neutrophils and activated macrophages in the alveoli, peribronchial, and perivascular region. The inflammogenic potential evaluated by the number of granulocytes divided by the treated surface area dose showed all types of REO NPs has much higher inflammogenic potential than DQ12, ZnO, and NiO NPs. The correlation plot between the number of granulocytes and the potential for reactive ox...Continue Reading

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Citations

Mar 25, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Qiuhan HuaYiguo Jiang
Jun 12, 2020·Environmental Science and Pollution Research International·Muhammad AdeelYukui Rui
Jun 19, 2021·Nanotoxicology·Amir Mohammad MalvandiMahmoud Abudayyak

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