High-Intensity Focused Ultrasound Ablation for Unresectable Primary and Metastatic Liver Cancer: Real-World Research in a Chinese Tertiary Center With 275 Cases

Frontiers in Oncology
Yongshuo JiHong Zhao

Abstract

This retrospective analysis was conducted to evaluate the feasibility and safety of high-intensity focused ultrasound ablation for primary liver cancer and metastatic liver cancer. Patients with liver cancer who received high-intensity focused ultrasound were included in this analysis, including a primary liver cancer cohort (n=80) and a metastatic liver cancer cohort (n=195). The primary endpoint of our research was tumor response. The secondary endpoints included survival outcomes, visual analog scale pain scores, alpha-fetoprotein relief, and complications. Objective response rate and disease control rate were observed to be 71.8% and 81.2%, respectively, in patients with primary liver cancer and were 63.7% and 83.2% in cases with metastatic liver cancer. Alpha-fetoprotein levels and visual analogue scale levels significantly decreased after treatment compared with the baseline levels in patients with primary liver cancer (p<0.05). Median overall survival was estimated to be 13.0 and 12.0 months in the primary liver cancer and metastatic liver cancer cohorts. The 1-year survival rate was 70.69% and 48.00%, respectively. Multivariate regression analysis showed that visual analogue scale ≥ 5, longest diameter ≥ 5 cm, and porta...Continue Reading

References

Feb 13, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Saravanan NamasivayamSanjay Saini
May 15, 2008·Journal of the National Cancer Institute·Josep M LlovetUNKNOWN Panel of Experts in HCC-Design Clinical Trials
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Feb 13, 2009·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Michael Yong ParkIn Sook Woo
Mar 24, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jonathan Sleeman, Patricia S Steeg
Jul 29, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Chuanxing LiFujun Zhang
Aug 24, 2010·AJR. American Journal of Roentgenology·Franco OrsiUmberto Veronesi
Dec 31, 2010·Frontiers of Medicine in China·Lian Zhang, Zhi-Biao Wang
Jan 29, 2011·Radiology·Muneeb AhmedS Nahum Goldberg
Mar 2, 2011·Journal of Cancer Research and Therapeutics·Franco OrsiLian Zhang
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Mar 12, 2011·Annals of Surgery·Kelvin K C NgSheung Tat Fan
May 24, 2011·World Journal of Clinical Oncology·Yu-Feng Zhou
Jun 8, 2011·Ultrasound in Medicine & Biology·Hiroyuki FukudaZhi-Biao Wanga
Nov 1, 2011·Ultrasound in Medicine & Biology·Guoliang XuGuobao Wang
Jun 16, 2012·World Journal of Surgery·Tan To CheungSheung Tat Fan
Dec 13, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Emmanuel TsochatzisAndrew K Burroughs
May 30, 2013·World Journal of Gastroenterology : WJG·Tan To CheungChung Mau Lo
Jul 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shan WangZhibiao Wang
Jan 24, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Tan To CheungChung Mau Lo
Apr 23, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kenneth S H ChokChung Mau Lo
May 27, 2014·American Society of Clinical Oncology Educational Book·Andrew S Kennedy
Jan 1, 2013·Journal of Therapeutic Ultrasound·Jean-Francois AubryWladyslaw M Gedroyc
Jan 23, 2015·Cancer Biology & Medicine·David LiDavid C Madoff
Jun 9, 2015·World Journal of Hepatology·Kenneth Sh Chok
Mar 25, 2016·Nature Reviews. Cancer·Patricia S Steeg
Feb 27, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Thierry de BaereDavid Malka
Mar 23, 2017·Journal of Hepatology·Peter R GalleLuigi Bolondi
May 10, 2017·Chinese Clinical Oncology·Ali A MokdadAdam C Yopp
Jun 13, 2017·Journal of Oncology Practice·Nicole E RichAmit G Singal

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Citations

Apr 4, 2021·Diagnostics·Terrence Ch HuiUei Pua
Apr 11, 2021·Journal of Vascular Surgery. Venous and Lymphatic Disorders·James DanaheyNaiem Nassiri
May 24, 2021·Ultrasound in Medicine & Biology·Chandra Priya KarunakaranT Douglas Mast
Aug 1, 2021·Scientific Reports·Mrigendra B KarmacharyaChandra M Sehgal

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Methods Mentioned

BETA
biopsy

Software Mentioned

STATA
mRECIST

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