PMID: 9181449Jun 1, 1997Paper

High-intensity focused ultrasound ablation of the kidney in a large animal model

Journal of Endourology
N A WatkinG R ter Haar

Abstract

The purpose of this study was to establish the feasibility of noninvasive treatment of small renal tumors with high-intensity focused ultrasound (HIFU). A 1.69-MHz extracorporeal HIFU transducer of 150-mm focal length was used. In vitro experiments with excised porcine kidneys allowed determination of suitable exposure parameters to be tested in vivo. For short exposure times (< 2 seconds), the minimum energy required to produce acute thermal damage was 500 +/- 100 Wcm-2 per second. Porcine kidneys (N = 18) were treated in vivo at a depth of 40 mm from the skin surface, with acute damage detected in 13. Damage was macroscopically and histologically discrete and confined to the target area within the kidney. Skin induration was observed after treatment in nine cases, and there was one skin burn. Transducer developments to prevent this morbidity and to improve energy deposition within the target are discussed.

References

Jan 1, 1979·Ultrasound in Medicine & Biology·J C Bamber, C R Hill
Jul 1, 1977·IEEE Transactions on Bio-medical Engineering·L A FrizzellC W Fridd
Nov 1, 1992·Journal of Computer Assisted Tomography·H E ClineF A Jolesz
Jan 1, 1991·European Urology·G VallancienJ André-Bougaran
Jan 1, 1990·Ultrasound in Medicine & Biology·B E BillardR B Roemer
Dec 1, 1994·The Journal of Urology·S MadersbacherM Marberger
May 1, 1995·Journal of Magnetic Resonance Imaging : JMRI·K HynynenF A Jolesz
Jan 1, 1993·European Urology·G VallancienJ Bougaran
Mar 1, 1994·The British Journal of Radiology·M G VaughanJ W Hopewell
Jan 1, 1996·Ultrasound in Medicine & Biology·N A WatkinI Rivens
Feb 1, 1996·Journal of Endourology·J B AdamsL R Davoussi

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Citations

Mar 21, 2008·Der Urologe. Ausg. A·S Thüroff, C Chaussy
Jun 27, 2002·Current Urology Reports·Nicolette JanzenArie S Belldegrun
Jul 4, 2001·The Journal of Urology·R G Uzzo, A C Novick
Feb 14, 2006·Nature Clinical Practice. Urology·Christian ChaussyAlbert Gelet
Dec 4, 2002·BJU International·E A DickW M W Gedroyc
Jun 8, 2001·Journal of Endourology·D B Johnson, S Y Nakada
Dec 10, 2002·Journal of Endourology·Ryan F PatersonJames A McAteer
Nov 19, 2003·Journal of Endourology·Raymond J Leveillee, Michael F Hoey
Nov 19, 2003·Journal of Endourology·Stephan Madersbacher, Michael Marberger
Apr 16, 2005·The Cancer Journal·Edouard J TrabulsiLeonard G Gomella
Dec 6, 2006·Ultrasound Quarterly·Thomas A Leslie, James E Kennedy
Jan 10, 2009·Advances in Urology·Jose Rubio BrionesEduardo Solsona Narbón
Dec 21, 2007·AJR. American Journal of Roentgenology·Theodore J DubinskyJoo Ha Hwang
Jun 22, 2001·AJR. American Journal of Roentgenology·A J AschoffJ S Lewin
Jun 20, 2007·Current Oncology·K G Kwan, E D Matsumoto
Dec 1, 2010·Indian Journal of Urology : IJU : Journal of the Urological Society of India·G NabiA Melzer
Sep 23, 2003·The British Journal of Radiology·J E KennedyD Cranston
Oct 24, 2009·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Jongbum Seo, Jaemoon Lee
Dec 20, 2008·The Journal of Urology·Marcelo A OrvietoArieh Shalhav
Dec 12, 2007·Techniques in Vascular and Interventional Radiology·Servet TatliStuart G Silverman
Dec 18, 2009·Journal of Surgical Oncology·Jay D RamanJeffrey A Cadeddu
Jun 29, 2004·Ultrasound in Medicine & Biology·James E KennedyDavid Cranston
Nov 12, 2003·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Binh C TranCharles A Cain
Jan 5, 2002·IEEE Transactions on Bio-medical Engineering·N M FriedS B Solomon
May 7, 2002·The Journal of Urology·William W RobertsStephen B Solomon
Sep 24, 2005·Ultrasound in Medicine & Biology·Michael R BaileyAndrew P Evan
Jul 24, 2004·Magnetic Resonance Imaging Clinics of North America·J Louis Hinshaw, Fred T Lee
Jan 31, 2002·Annual Review of Medicine·Andrew C Novick
Dec 13, 2005·Expert Review of Anticancer Therapy·Axel HäckerPeter Alken
Feb 22, 2005·BJU International·Michael MarbergerJ E Kennedy
Jun 21, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·T A Leslie, J E Kennedy
Jun 29, 2011·Expert Review of Anticancer Therapy·Thomas ClementsJay D Raman
Apr 15, 2003·Current Opinion in Urology·Axel HäckerKai Uwe Koehrmann
Jun 20, 2002·Current Opinion in Urology·Ryan F PatersonJames E Lingeman

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