High intensity focused ultrasound (HIFU) ablation of benign thyroid nodules - a systematic review

Journal of Therapeutic Ultrasound
Brian Hung-Hin Lang, Arnold L H Wu

Abstract

With an increasing number of imaging studies being done nowadays, the number of incidentally discovered thyroid nodules is expected to rise. Although many of these nodules are small and benign in nature, some do grow and may cause pressure and/or thyrotoxic symptoms. Surgical resection has traditionally been recommended for symptomatic nodules but is associated with risk of hypothyroidism, bleeding, infection, and nerve damage. High intensity focused ultrasound (HIFU) is one of the non-surgical thermal ablation techniques that may serve as an alternative in the treatment of benign thyroid nodules. The present review is to systematically evaluate the efficacy and safety of HIFU ablation. We comprehensively searched all studies that evaluated the use of HIFU ablation as a treatment of benign thyroid nodules from Medline (PubMed) and Cochrane Library electronic databases using specific keywords. All titles identified by the search strategy were independently screened by two authors. Case reports, animal studies, editorials, expert opinions, reviews without original data and studies on pediatric population were excluded. Multiple reports of the same dataset were assessed and the most representative and updated report of a study was...Continue Reading

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Citations

Apr 11, 2018·Scientific Reports·Tali IlovitshKatherine W Ferrara
Jul 19, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Adrien Ben HamouHerve Monpeyssen
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Jun 4, 2020·The Journal of Clinical Endocrinology and Metabolism·Giorgio GraniCosimo Durante
May 26, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Brian H H LangEstella P M Ma
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Oct 12, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Marion C SewardPavel S Yarmolenko
Feb 11, 2020·Frontiers in Endocrinology·Dario TuminoFabio Maino
Nov 24, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Hervé MonpeyssenEnrico Papini
May 27, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·John F SwietlikTimothy J Ziemlewicz
Jun 6, 2021·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Xinrui ZhangAndreas Melzer

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Methods Mentioned

BETA
surgical resection
biopsy

Software Mentioned

Echopulse
Beamotion
birdview

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