High-intensity interval training in the therapy and aftercare of cancer patients: a systematic review with meta-analysis

Journal of Cancer Survivorship : Research and Practice
Hendrik MugeleMoritz Schumann

Abstract

This review and meta-analysis aimed to evaluate the effects of high-intensity interval training (HIIT) compared to usual care (UC) or moderate-intensity training (MIE) on physical fitness and health-related outcomes in cancer patients across all stages of therapy and aftercare. Databases were systematically searched in accordance with the PRISMA guidelines until October 4th, 2018. Eligibility criteria included adult patients of various cancer types, performing HIIT vs. UC or MIE. Outcomes of interest included physical fitness (cardiorespiratory fitness [VO2peak] and functional capacity) and health-related outcomes (body composition, quality of life, cancer-related fatigue, and blood-borne biomarkers). Mean differences (MD) were calculated and pooled to generate effect sizes for VO2peak. The search identified 1453 studies, out of which 12 articles were included. The average duration of interventions was 6.7 ± 3.0 weeks, with 2.8 ± 0.5 sessions per week. The meta-analysis for VO2peak showed superiority of HIIT compared to UC (MD 3.73; 95% CI 2.07, 5.39; p < 0.001) but not MIE (MD 1.36; 95% CI - 1.62, 4.35; p = 0.370). Similarly, no superior effects of HIIT compared to MIE were found for quality of life or changes in lean mass, wh...Continue Reading

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Citations

Aug 27, 2019·Current Opinion in Oncology·Erin M Gibson, Michelle Monje
Jul 30, 2020·Journal of Physiology and Biochemistry·Guiping WangZhongxiao Wan
Nov 16, 2019·Medicine and Science in Sports and Exercise·Kathrin SchlüterFriederike Rosenberger
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May 22, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kyuwan LeeChristina M Dieli-Conwright
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Oct 30, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Alejandro Heredia-CiuróMarie Carmen Valenza
Aug 12, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Efthymios PapadopoulosDaniel Santa Mina

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