High-intensity physical exercise increases serum α -klotho levels in healthy volunteers

Journal of Circulating Biomarkers
Sven-Jean TanStephen G Holt

Abstract

The recently discovered klotho proteins have roles in a diverse range of metabolic processes with the oldest protein, α-klotho, implicated in various cellular pathways in energy, glucose, and phosphate metabolism. Circulating soluble klotho (sKl), derived from membrane α-klotho cleavage, not only has effects on ion channels and insulin signaling pathways, but is inversely associated with mortality. Effects of physical exercise on sKl have not been well studied. The effect of a single high-intensity standardized exercise on sKl and serum phosphate (sPi) levels in healthy adults was investigated. A standard Bruce protocol treadmill exercise was undertaken by 10 fasting healthy volunteers. sKl, sPi, and blood glucose levels were measured in samples collected 1-week prior, immediately pre (Tpre), 0 (Tpost), 30 (T30), 240 (T240) min, and 1-week after exercise. Median (interquartile range) age of participants was 47.5 (44-51) years; five (50%) were male. All study participants achieved at least 90% predicted maximum heart rate (MHR). sKl increased acutely after exercise (Tpre median 448 pg/mL vs. Tpost median 576 pg/mL; p < 0.01). There was a nonsignificant sPi decline at T30 (Tpre 0.94 ± 0.12 mmol/L vs. T30 0.83 ± 0.22 mmol/L). Exer...Continue Reading

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Citations

Jan 11, 2020·Frontiers in Physiology·Zhijian RaoRengfei Shi
Jun 25, 2019·The Journal of Nutrition, Health & Aging·J E Morley
Mar 28, 2020·Journal of the American Heart Association·Jonathan P LawCharles J Ferro
Jan 9, 2021·Nutrition & Diabetes·Roeland J W MiddelbeekLaurie J Goodyear
Oct 23, 2020·Ageing Research Reviews·Stephen F VatnerDorothy E Vatner
Oct 30, 2021·Physiological Reports·Takuma Morishima, Eisuke Ochi

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Methods Mentioned

BETA
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SPSS
GraphPad Prism

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