Nov 1, 2018

High interictal connectivity within the resection zone is associated with favorable post-surgical outcomes in focal epilepsy patients

BioRxiv : the Preprint Server for Biology
Preya ShahBrian Litt

Abstract

Objective: Patients with drug-resistant focal epilepsy are often candidates for invasive surgical therapies. In these patients, it is necessary to accurately localize seizure-generators to ensure seizure freedom following intervention. While intracranial electroencephalography (iEEG) is the gold standard for mapping networks for surgery, this approach requires inducing and recording seizures, which may cause patient morbidity. The goal of this study is to evaluate the utility of mapping interictal (non-seizure) iEEG networks to identify targets for surgical treatment. Methods: We analyze interictal iEEG recordings and neuroimaging from 27 focal epilepsy patients treated via surgical resection. We generate interictal functional networks by calculating pairwise correlation of iEEG signals across different frequency bands. We identify electrodes falling within surgically resected tissue (i.e. the resection zone), and compute node-level and edge-level synchrony in relation to the resection zone. We associate these metrics with post-surgical outcomes. Results: Greater overlap between resected electrodes and highly synchronous electrodes is associated with favorable post-surgical outcomes. Additionally, good outcome patients have sig...Continue Reading

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Mentioned in this Paper

Study
Biological Neural Networks
Zone
Brain Diseases
Morbidity Aspects
Electroencephalography
Epilepsy
Implants
Excision
Drug Resistant Epilepsy

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