High Intraperitoneal Interleukin-6 Levels Predict Peritonitis in Peritoneal Dialysis Patients: A Prospective Cohort Study

American Journal of Nephrology
Xiaoxiao YangWei Fang

Abstract

To evaluate the predictive value of dialysate interleukin-6 (IL-6) representing local subclinical intraperitoneal inflammation for the development of peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients. Stable prevalent CAPD patients were enrolled in this prospective study. IL-6 concentration in the overnight effluent was determined and expressed as the IL-6 appearance rate (IL-6AR). Patients were divided into 2 groups according to the median of IL-6AR and prospectively followed up until the first episode of peritonitis, cessation of PD, or the end of the study (December 30, 2017). The utility of IL-6AR in predicting peritonitis-free survival was analyzed using the Kaplan-Meier and Cox proportional hazards models. A total of 149 patients were enrolled, including 72 males (48%) with mean age 52.0 ± 13.6 years and median PD duration 26 (5.9-45.5) months. During follow-up, 7,923 patient months were observed and 154 episodes of peritonitis occurred in 82 patients. Previous peritonitis episodes were significantly associated with log dialysate IL-6AR levels (β = 0.187 [0.022-0.299], p = 0.023). Patients in the high IL-6AR group showed a significantly inferior peritonitis-free survival when compared with their cou...Continue Reading

References

Dec 16, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J Y Yeun, G A Kaysen
Mar 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K N LaiJ C Leung
Apr 11, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cheuk-Chun SzetoPhilip Kam-Tao Li
Aug 20, 2003·The Journal of Clinical Investigation·Rachel M McLoughlinNicholas Topley
Aug 7, 2004·Blood Purification·Terhi A MartikainenCarola Grönhagen-Riska
Feb 3, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Than N OoAllan J Collins
May 2, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Sharon J NessimSarbjit V Jassal
Jun 23, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Michaela C BrownUNKNOWN Scottish Renal Registry
Feb 4, 2010·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Denise E SampimonRaymond T Krediet
Apr 9, 2010·Kidney International·David W JohnsonKathryn J Wiggins
Jul 2, 2011·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Joanna R GhaliStephen P McDonald
Jul 9, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Luis C MartinUNKNOWN Brazilian Peritoneal Dialysis Multicenter Study BRAZPD Group
Aug 2, 2011·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Michaela C BrownUNKNOWN Scottish Renal Registry
May 2, 2012·Mediators of Inflammation·Gilberto BaroniRoberto Pecoits-Filho
May 26, 2012·Journal of the American Society of Nephrology : JASN·Neil BoudvilleDavid W Johnson
Sep 7, 2013·Journal of the American Society of Nephrology : JASN·Mark LambieUNKNOWN Global Fluid Study Investigators
Jun 11, 2016·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Philip Kam-Tao LiDavid W Johnson

❮ Previous
Next ❯

Citations

Dec 17, 2019·American Journal of Physiology. Renal Physiology·Xiaoxiao YangWei Fang
Nov 3, 2021·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Dongyuan ChangJie Dong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.