High-irradiance CXL combined with myopic LASIK: flap and residual stroma biomechanical properties studied ex-vivo

The British Journal of Ophthalmology
Anastasios J KanellopoulosJoseph B Ciolino

Abstract

To evaluate ex vivo biomechanical and enzymatic digestion resistance differences between standard myopic laser in-situ keratomileusis (LASIK) compared with LASIK+CXL, in which high-irradiance cross-linking (CXL) is added. Eight human donor corneas were subjected to femtosecond-assisted myopic LASIK. Group A (n=4) served as a control group (no CXL). The corneas in LASIK+CXL group B were subjected to concurrent prophylactic high-irradiance CXL (n=4). Saline-diluted (0.10%) riboflavin was instilled on the stroma, subsequently irradiated with UV-A through the repositioned flap. The cornea stroma and flap specimens were separately subjected to transverse biaxial resistance measurements; biomechanical differences were assessed via stress and Young's shear modulus. Subsequently, the specimens were subjected to enzymatic degradation. For the corneal stroma specimen, stress at 10% strain was 128±11 kPa for control group A versus 293±20 kPa for the LASIK+CXL group B (relative difference Δ=+129%, p<0.05). The stress in group B was also increased at 20% strain by +68% (p<0.05). Shear modulus in group B was increased at 10% strain by +79%, and at 20% strain by +48% (both statistically significant, p<0.05). The enzymatic degradation time to ...Continue Reading

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Citations

Jun 4, 2016·Journal of Cataract and Refractive Surgery·Shihao ChenQinmei Wang
Aug 16, 2016·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Paul W FlavahanSanjay Mantry
Feb 14, 2017·Journal of Refractive Surgery·Sabine Kling, Farhad Hafezi
Mar 7, 2017·Journal of Refractive Surgery·Andrea CruzatJoseph B Ciolino
Jun 7, 2017·Journal of Refractive Surgery·J Bradley RandlemanGiuliano Scarcelli
Nov 28, 2017·Cornea·Saleh A AlageelJoseph B Ciolino
Jun 17, 2020·Investigative Ophthalmology & Visual Science·Sabine KlingFarhad Hafezi
May 7, 2016·Current Opinion in Ophthalmology·Minoru Tomita
Oct 2, 2019·Taiwan Journal of Ophthalmology·Michael TsatsosNikolaos Ziakas
May 18, 2016·Asia-Pacific Journal of Ophthalmology·Angelique Pillar, Ronald Krueger

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