High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma

Journal of Clinical Pathology
Qin JinGang Liu

Abstract

Kinesin family member 11 (Kif11) is a member of the kinesin family motor proteins, which is associated with spindle formation and tumour genesis. In this study, we investigated the relationship between Kif11 expression and clear cell renal cell carcinoma (CCRCC) development. The relationship between Kif11 expression and CCRCC development was analysed by quantitative real-time (qRT)-PCR analyses, and tissue immunohistochemistry. The prognostic significance of Kif11 expression was explored by univariable and multivariable survival analyses of 143 included patients. Furthermore, SB743921 was used as a specific Kif11 inhibitor to treat 786-O cells with the epithelial to mesenchymal transition (EMT) process analysed by qRT-PCR, and cell survival rates analysed with Annexin V-FITC/PI staining followed by flow cytometric analyses. Disease-free survival curves of Kif11 with different cancers and the relationships between Kif11 and the von Hippel-Lindau disease tumour suppressor gene (VHL), and proliferating cell nuclear antigen (PCNA) in kidney cancer were further analysed using the GEPIA database. The levels of Kif11 mRNA were significantly higher in CCRCC tissues compared with corresponding non-cancerous tissues. The results of immun...Continue Reading

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Citations

Oct 17, 2019·Journal of Biochemical and Molecular Toxicology·Hongmei YanLi Zhang
May 23, 2020·Journal of Molecular Neuroscience : MN·Xin PanYuqi Zhang
Oct 8, 2020·Technology in Cancer Research & Treatment·Liqi LiDong Meng
Jan 26, 2021·Cellular and Molecular Neurobiology·Bin LiuGuoliang Du
Jul 3, 2021·Cancers·Anna Klimaszewska-WiśniewskaMaciej Gagat
Jul 5, 2021·The International Journal of Biochemistry & Cell Biology·Meng-Jun QiuZhi-Fan Xiong

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Methods Mentioned

BETA
FACS
PCR
surgical resection
xenografts

Software Mentioned

GEPIA
Statistical Package for the Social Sciences software ( SPSS

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