High-level cytoplasmic claudin 3 expression is an independent predictor of poor survival in triple-negative breast cancer

BMC Cancer
Anniina JääskeläinenPeeter Karihtala

Abstract

The subtype of claudin-low breast cancer can be reliably determined only by gene-expression profiling. Attempts have been made to develop immunohistochemical surrogates, which nearly always focus on membranous claudin expression. We assessed the immunohistochemical expression of both membranous and cytoplasmic claudins 3, 4 and 7 in a series of 197 non-metastatic breast cancers, enriched with triple-negative breast cancers (TNBCs; 60%). The expression of epithelial-to-mesenchymal transition-regulating transcription factors Sip1, Zeb1 and vimentin had previously been determined in the same material. In multivariate analysis, strong cytoplasmic claudin 3 expression was associated with poor relapse-free survival (RFS), disease-free survival, distant disease-free survival, breast cancer-specific survival and overall survival among TNBC patients (for RFS, RR 5.202, 95% CI 1.210-22.369, p = 0.027, vs. T-class, RR 0.663, 95% CI 0.168-2.623, p = 0.558, and N-class, RR 3.940, 95% CI 0.933-16.631, p = 0.062). Cytoplasmic claudin 3 expression was also associated with strong nuclear Sip1 expression (p = 0.000053), TNBC phenotype (p = 0.012) and within them, non-basal-like phenotype (p = 0.026). Cytoplasmic claudin 7 was associated with dis...Continue Reading

References

Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenCharles M Perou
Jul 29, 2005·Cytopathology : Official Journal of the British Society for Clinical Cytology·T SauerO Naess
Apr 25, 2007·Journal of Cell Science·Karl Matter, Maria Susana Balda
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maggie C U CheangTorsten O Nielsen
Aug 30, 2008·Pathology Oncology Research : POR·Janina KulkaAnna-Mária Tokés
Jan 15, 2009·International Journal of Cancer. Journal International Du Cancer·Fiona LaniganWilliam M Gallagher
Sep 4, 2010·Breast Cancer Research : BCR·Aleix PratCharles M Perou
Sep 15, 2010·Annals of Surgical Oncology·Chang Ohk SungSeok-Hyung Kim
Feb 1, 2011·FEBS Letters·Katsuhiko MinetaSachiko Tsukita
May 31, 2011·Respiratory Research·Ylermi Soini
Aug 13, 2011·Annals of Surgical Oncology·Kosuke TsutsumiMasao Tanaka
Dec 12, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shaolei LuEvgeny Yakirevich
May 25, 2013·Applied Immunohistochemistry & Molecular Morphology : AIMM·Panagiota KolokythaKitty Pavlakis
Oct 4, 2014·Molecular Cancer·Renaud SabatierFrançois Bertucci
Nov 25, 2014·BMC Cancer·Laura S JiwaCathy B Moelans
Dec 3, 2014·Annals of Diagnostic Pathology·Mona A Abd-Elazeem, Marwa A Abd-Elazeem
Mar 31, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Juanjuan CheBangwei Cao
Jul 23, 2016·Virchows Archiv : an International Journal of Pathology·Yusuke OnoNorimasa Sawada
Sep 15, 2016·Pflügers Archiv : European journal of physiology·Makoto OsanaiNorimasa Sawada

❮ Previous
Next ❯

Citations

Aug 31, 2020·Pathology, Research and Practice·Claudia Fabiana Joca de ArrudaSilvia Vanessa Lourenço
Jul 10, 2021·Journal of Cancer Research and Clinical Oncology·Olga P PopovaAlexey A Ivanov

❮ Previous
Next ❯

Software Mentioned

SPSS Statistics

Related Concepts

Related Feeds

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.