PMID: 9177226Jun 10, 1997Paper

High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers

Proceedings of the National Academy of Sciences of the United States of America
S FredersdorfX Lu

Abstract

The expression of cyclin-dependent kinase inhibitor p27(kip1) in human tumors and normal tissues was investigated using a panel of novel anti-p27(kip1) mAbs. An inverse correlation between expression of p27(kip1) and cell proliferation was generally observed after analyzing its expression in 25 different normal human tissues. In some highly proliferative human breast cancer cells, however, high level p27(kip1) expression was seen, indicating the existence of a mechanism by which some growing tumor cells may tolerate this inhibitor of cell cycle progression. Detailed studies demonstrated a correlation between the high level expression of p27(kip1) and cyclin D1 in human breast cancer cells. There was also an inverse correlation between the expression of p27(kip1) and the degree of tumor malignancy in human breast and colorectal cancers, indicating that p27(kip1) may be a useful prognostic marker in these cancers.

References

Dec 1, 1994·Current Opinion in Cell Biology·G F Draetta
Dec 1, 1994·Current Opinion in Cell Biology·S J Elledge, J W Harper
Apr 1, 1994·Molecular and Cellular Biology·C E DabrowskiP A Schaffer
Apr 22, 1996·International Journal of Cancer. Journal International Du Cancer·C GillettD Barnes

❮ Previous
Next ❯

Citations

Jul 9, 1999·The Journal of Pathology·P L FernándezA Cardesa
Aug 12, 1998·International Journal of Cancer. Journal International Du Cancer·T AnayamaS Ogoshi
Mar 4, 2000·Journal of Cellular Physiology·J Slingerland, M Pagano
Mar 4, 2000·Journal of Cellular Physiology·A SgambatoI B Weinstein
Jan 14, 2000·Journal of Clinical Laboratory Analysis·D F LiuJ Willis
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ItoM Monden
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Lynya I TalleyAndra R Frost
Dec 19, 2001·The Journal of Pathology·Franca De PaolaAnnalisa Volpi
Oct 26, 1999·Brain Tumor Pathology·S NakasuJ Handa
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·D M Barnes
Nov 3, 2001·Pathology Oncology Research : POR·J TímárL Kopper
Dec 26, 2006·Medical Molecular Morphology·Yasunobu Matsuda, Takafumi Ichida
May 4, 2013·Medical Molecular Morphology·Yasunobu MatsudaTakafumi Ichida
Nov 3, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J M Fernández-CebriánM Ramos Fernández
May 19, 2004·The International Journal of Biochemistry & Cell Biology·Tarik Möröy, Christoph Geisen
Sep 6, 2003·The Journal of Surgical Research·Klaus GüntherClaus Rödel
Dec 22, 1999·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S IshiharaM Mori
Jul 9, 1999·Cancer Letters·A M HuiS Hirohashi
Aug 24, 1999·Cancer Letters·J S ChuK J Chang
Nov 19, 1997·Neuroscience Letters·R PivaD Schiffer
Apr 8, 1998·Current Opinion in Genetics & Development·W Krek
Sep 6, 2003·Surgical Oncology·Morton S KahlenbergNicholas J Petrelli
Aug 16, 2001·Trends in Endocrinology and Metabolism : TEM·J S FosterJ Wimalasena
Feb 21, 2002·Oral Oncology·Mark Yen-Ping KuoChun-Pin Chiang
Mar 5, 1999·Breast Cancer Research and Treatment·D M Barnes, C E Gillett
Mar 5, 1999·Breast Cancer Research and Treatment·S CariouJ M Slingerland
Aug 24, 2001·Breast Cancer Research and Treatment·M LeivonenC Haglund
Mar 5, 2004·Breast Cancer Research and Treatment·Catherine F Welsh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.