High level of androgen receptor is associated with aggressive clinicopathologic features and decreased biochemical recurrence-free survival in prostate: cancer patients treated with radical prostatectomy

The American Journal of Surgical Pathology
Rile LiGustavo Ayala

Abstract

Prostate cancer (PCa) is androgen dependent and is regulated by androgen/androgen receptor (AR) signaling pathway. However, the clinical significance of AR is in question. In this regard, we have correlated levels of AR expression with some well-established clinical and pathologic parameters and assessed the prognostic value of AR expression in PCa patients treated with radical prostatectomy. A total of 640 cases treated with radical prostatectomy were used to build tissue microarrays. Normal prostate tissue, benign prostatic hyperplasia, and index tumor were cored in triplicate (0.6 mm). An array (2 mm) of 177 metastatic PCa was built as well. Slides were immunostained with an antibody to AR and Ki-67 and digitized. Correlations between AR expression and clinicopathologic variables were analyzed by the Spearman test. Biochemical recurrence-free survival analysis was performed using Kaplan-Meier analysis, and Cox proportional hazard regression was used to determine the probability of disease recurrence. AR was found in epithelial nuclei of both benign and cancer tissues. AR index was higher in normal prostate tissues than that in PCa and benign prostatic hyperplasia and decreased in metastases than PCa. High level of AR express...Continue Reading

References

May 1, 1975·Journal of Steroid Biochemistry·N BruchovskyD J Sutherland
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J R NewmarkE R Barrack
Jan 1, 1983·The Journal of Clinical Endocrinology and Metabolism·D M WilbertJ D Wilson
Jan 1, 1984·The Prostate·J T Isaacs
Nov 1, 1994·The Prostate·T M Wheeler, R M Lebovitz
May 25, 1995·The New England Journal of Medicine·M E TaplinS P Balk
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·H MiyamotoC Chang
Aug 1, 1998·The Journal of Biological Chemistry·K E KnudsenW K Cavenee
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·H MiyamotoC Chang
Mar 13, 1999·The Journal of Biological Chemistry·N FujimotoC Chang
Mar 19, 1999·The Journal of Urology·S D SweatD G Bostwick
Nov 14, 2000·Microscopy Research and Technique·Z CuligH Klocker
Oct 3, 2002·Cancer Letters·Jose D Debes, Donald J Tindall

❮ Previous
Next ❯

Citations

Sep 20, 2011·World Journal of Urology·Myles C HodgsonIrina U Agoulnik
Jun 24, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mark A Rubin
Feb 14, 2007·Prostate Cancer and Prostatic Diseases·E RichterA Dobi
Apr 19, 2007·Prostate Cancer and Prostatic Diseases·K SircarM Trifiro
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yuanjie NiuChawnshang Chang
Jan 26, 2006·The American Journal of Surgical Pathology·W Glenn McCluggageTerence P Rollason
Dec 21, 2010·Cancer Research·Jianghua WangMichael Ittmann
May 31, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wendong YuMichael Ittmann
Jun 9, 2007·The Journal of Clinical Investigation·Carlos Cordon-CardoMichael J Donovan
Dec 19, 2006·Theoretical Biology & Medical Modelling·Raúl A Ruggiero, Oscar D Bustuoabad
Oct 3, 2012·PloS One·Roble G BedollaAddanki P Kumar
Apr 29, 2014·Human Pathology·Adriana OlarGustavo Ayala
Aug 21, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·D RadesF Noack
Nov 29, 2012·Journal of Cancer Research and Clinical Oncology·Naveen Kachroo, Vincent J Gnanapragasam
May 13, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Tsutomu Nishiyama
May 13, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·James L Mohler
Dec 27, 2005·International Journal of Radiation Oncology, Biology, Physics·John Petersen
Apr 14, 2016·Journal of Cancer Research and Therapeutics·Irma HusainNuzhat Husain
Sep 20, 2006·Expert Opinion on Therapeutic Targets·Dominik R Berthold, Malcolm J Moore
Mar 29, 2012·Scandinavian Journal of Urology and Nephrology·Andreas JosefssonAnders Bergh
May 15, 2015·Endocrine-related Cancer·Gustavo AyalaMichael Ittmann
Nov 12, 2013·Journal of the Egyptian National Cancer Institute·Wesam M OsmanHoda H Abou Gabal
Aug 5, 2014·The American Journal of Pathology·Mandeep SinghPeng Lee
May 26, 2009·Steroids·Irina U Agoulnik, Nancy L Weigel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.