High Level of Depressive Symptoms at Repeated Study Visits and Risk of Coronary Heart Disease and Stroke over 10 Years in Older Adults: The Three-City Study

Journal of the American Geriatrics Society
Renaud PéquignotJean-Philippe Empana

Abstract

Baseline depressive symptoms have been consistently associated with the onset of cardiovascular disease (CVD). Since depressive symptoms vary over time in elderly persons, and to help clarify whether or not depression is an etiological factor for CVD, we quantified the association between the course of depressive symptoms and occurrence of first coronary heart disease (CHD) and stroke events in older adults. A population-based prospective observational study. Participants were randomly selected from the electoral rolls of three large French cities. A total of 9,294 participants were examined at baseline between 1999 and 2001, and thereafter at repeated study visits over 10 years. High levels of depressive symptoms (HLDS) were defined as a score ≥16 on the 20-item Center for Epidemiologic Studies Depression Scale. The number of study visits with HLDS was used as a time dependent variable in Cox proportional hazard models. There were 7,313 participants (36.6% males) aged 73.8 ± 5.4 years with no history of CHD, stroke or dementia at baseline. After a median follow-up of 8.4 years (SD 2.3 years), 629 first CHD or stroke events occurred. After adjustment for sociodemographic characteristics and vascular risk factors, the risk of CH...Continue Reading

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Nov 4, 2016·BMC Medicine·Howard J AizensteinOren Tene
Nov 18, 2016·Nature Reviews. Cardiology·Robert M Carney, Kenneth E Freedland
Feb 28, 2018·Neuroimmunomodulation·Ruei-An ChenYi-Yung Hung
Nov 24, 2018·Journal of Aging and Health·Rebecca BendayanGraciela Muniz-Terrera
Jan 18, 2019·Journal of the American Geriatrics Society·Renaud PéquignotJean-Philippe Empana
Jul 12, 2017·Current Medical Research and Opinion·Wei YuShanlian Hu
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Oct 29, 2020·Revista brasileira de enfermagem·Sabrina Piccinelli Zanchettin Silva, Silvia Cristina Mangini Bocchi

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