High level of fecal calprotectin at age 2 months as a marker of intestinal inflammation predicts atopic dermatitis and asthma by age 6

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
L OrivuoriPASTURE study group

Abstract

Gut microbiota and intestinal inflammation regulate the development of immune-mediated diseases, such as allergies. Fecal calprotectin is a biomarker of intestinal inflammation. We evaluated the association of early-age fecal calprotectin levels to the later development of allergic diseases in children from farming and non-farming environments and further studied the effect of gut microbiota on the fecal calprotectin levels. Fecal calprotectin was measured from 758 infants participating in the PASTURE study at the age of 2 months using the ELISA method. Serum-specific IgE levels were measured at 6 years of age. Data of environmental factors, doctor-diagnosed atopic dermatitis (AD) and asthma were collected by questionnaire. Multivariate logistic regression models were used for analysis. The composition of fecal microbiota was analysed in a subgroup of 120 infants with 16S rRNA pyrosequencing. The effect of Escherichia coli lipopolysaccharide (LPS) on in vitro monocyte IL-10 secretion was studied by flow cytometry. The infants with high fecal calprotectin levels at 2 months, that is above the 90th percentile, had an increased risk of developing AD and asthma/asthmatic bronchitis by the age of 6 years (aOR 2.02 (1.06-3.85) and 2....Continue Reading

References

Mar 1, 1995·The European Respiratory Journal·M I AsherA W Stewart
Jan 1, 1993·Dermatology : International Journal for Clinical and Investigative Dermatology
Jun 1, 1997·Molecular Pathology : MP·B JohneI Dale
May 26, 1999·Clinical and Experimental Immunology·C HessleA E Wold
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hanne R ChristensenJames J Pestka
Mar 6, 2002·The Journal of Experimental Medicine·Mathias W HornefAgneta Richter-Dahlfors
Apr 20, 2002·Journal of Pediatric Gastroenterology and Nutrition·Jarle Rugtveit, Magne K Fagerhol
Dec 18, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Xavier BasagañaUNKNOWN AMICS study
Feb 20, 2003·The Journal of Experimental Medicine·Iris CaramalhoJocelyne Demengeot
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dunia RodríguezMomtchilo Russo
Sep 26, 2003·Journal of Pediatric Gastroenterology and Nutrition·Ulrika Lorentzon FagerbergYigael Finkel
Feb 27, 2004·Nucleic Acids Research·Wolfgang LudwigKarl-Heinz Schleifer
May 22, 2004·BioTechniques·Zhongtang Yu, Mark Morrison
Jul 9, 2004·The Journal of Allergy and Clinical Immunology·Emma PohjavuoriErkki Savilahti
Mar 26, 2005·Science·Thomas T Macdonald, Giovanni Monteleone
Mar 10, 2007·Endocrine, Metabolic & Immune Disorders Drug Targets·M E BaldassarreN Laforgia
Apr 7, 2007·Journal of Pediatric Gastroenterology and Nutrition·Stina JosefssonMagnus Domellöf
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Jun 29, 2007·Neonatology·Miguel GueimondeErika Isolauri
Feb 13, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E MarschanO Vaarala
Mar 25, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R Berni CananiR Troncone
Jul 18, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J BortolattoM Russo
Nov 14, 2008·Nucleic Acids Research·J R ColeJ M Tiedje
Jan 31, 2009·European Journal of Immunology·Lei JiaoXi Yang
Jan 8, 2010·Journal of Clinical Gastroenterology·Vildan ErtekinNuri Bakan
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Carlotta De FilippoPaolo Lionetti
Sep 8, 2010·Journal of Pediatric Gastroenterology and Nutrition·Nathalie KapelChristophe Dupont
Jan 25, 2011·Applied and Environmental Microbiology·Bartholomeus van den BogertMichiel Kleerebezem
Mar 12, 2011·Clinical and Experimental Immunology·S-H ChungC-K Joo
Aug 16, 2012·Current Opinion in Allergy and Clinical Immunology·Gabriela Wlasiuk, Donata Vercelli
Oct 10, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L OrivuoriUNKNOWN PASTURE Study Group
Jan 10, 2014·Allergy, Asthma & Immunology Research·Omer F BeşerFügen Ç Cokuğraş
Feb 4, 2014·Applied and Environmental Microbiology·Rosanne HertzbergerM Joost Teixeira de Mattos
Mar 19, 2014·Journal of Gastroenterology and Hepatology·Keisuke InoueHiroshi Tamai
Apr 1, 2014·FEBS Letters·Michele M KosiewiczPascale Alard

❮ Previous
Next ❯

Citations

Nov 26, 2015·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Eshia Moodley-GovenderAnna Coutsoudis
Jul 27, 2015·Current Opinion in Immunology·Bianca Schaub, Donata Vercelli
May 9, 2016·The Journal of Allergy and Clinical Immunology·Chrysanthi SkevakiCatherine A Thornton
Jun 3, 2016·Current Opinion in Allergy and Clinical Immunology·Kotryna Simonyte SjödinChristina E West
Sep 30, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G RobertsJ A Woodfolk
Nov 1, 2016·Nature Reviews. Microbiology·Kurtis F BuddenPhilip M Hansbro
Oct 27, 2016·Critical Reviews in Microbiology·Yang HeJunshuai Wang
Oct 19, 2016·Current Opinion in Pulmonary Medicine·Aran SinganayagamSebastian L Johnston
Apr 10, 2017·Early Human Development·Yoo Mi LeeSu Jin Jeong
Jan 17, 2017·Journal of Clinical Laboratory Analysis·Joo Young SongSu Jin Jeong
Jul 12, 2017·International Journal of Molecular Sciences·Mª Amelia Gomez-LlorenteCarolina Gomez-Llorente
Aug 5, 2017·European Journal of Immunology·Jeremy P McAleer, Jay K Kolls
Oct 17, 2018·Allergy·Nonhlanhla LunjaniLiam O'Mahony
Oct 12, 2018·Archivum Immunologiae Et Therapiae Experimentalis·Anna BalatoGabriella Fabbrocini
May 22, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M ReigerC Traidl-Hoffmann
May 3, 2019·The British Journal of Dermatology·Y YuA Alikhan
Sep 15, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·B Polkowska-PruszyńskaD Krasowska
Aug 7, 2019·Experimental and Therapeutic Medicine·Emilia RusuGabriela Radulian
Jul 15, 2020·Expert Review of Respiratory Medicine·Benedetta BiagioniLorenzo Cecchi
Dec 29, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Sari PeuraAnders Larsson
Jul 26, 2017·Frontiers in Immunology·Isabelle Laforest-Lapointe, Marie-Claire Arrieta
Mar 14, 2018·The American Journal of Gastroenterology·Shelley A DeekeDaniel Figeys
Jun 4, 2020·International Journal of Molecular Sciences·Myoung-Ju KimYoung Her
Apr 20, 2019·Korean journal of pediatrics·Su Jin Jeong
Aug 24, 2019·Pediatric Research·Bethany M HenrickJennifer T Smilowitz
Jun 7, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Eila KujansuuOuti Vaarala
Dec 12, 2020·Gastroenterology·Eun Soo KimUNKNOWN Mount Sinai Road to Prevention Study Group
Feb 12, 2021·International Journal of Molecular Sciences·Ourania S KotsiouKonstantinos I Gourgoulianis
Aug 23, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Paweł LiśkiewiczJerzy Samochowiec
May 1, 2021·International Journal of Molecular Sciences·Dong Hoon ParkDae-Hyun Hahm
Jun 3, 2021·Children·Grigorios Chatziparasidis, Ahmad Kantar
Jun 11, 2021·The Australasian Journal of Dermatology·Wonsuck YoonYoung Yoo
Jul 3, 2021·International Journal of Molecular Sciences·Marcello CandelliFrancesco Franceschi
Aug 2, 2021·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Jan K NowakJarosław Walkowiak
Dec 22, 2021·Immunity, Inflammation and Disease·Jacob MashiahNitsan Maharshak

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