High level of serum AFP is an independent negative prognostic factor in gastric cancer

The International Journal of Biological Markers
Yueguang ChenQingsi He

Abstract

Gastric cancer with a high level of serum alpha fetoprotein (AFP) is uncommon and has unique clinicopathological features and a poorer prognosis. The aim of this research was to elucidate the clinicopathological and prognostic features of gastric cancer with a high level of AFP. The sera from 1,286 patients with gastric cancer treated at Qilu Hospital of Shandong University from January 2004 to December 2008 were analyzed preoperatively for AFP, CEA and CA19-9 levels after excluding active or chronic hepatitis, liver cirrhosis and hepatocellular carcinoma as well as preoperative distant metastasis. Patients were divided into 2 groups: 86 serum AFP-positive patients and 1,200 serum AFP-negative patients according to a cutoff of 20 ng/mL. The clinicopathological features and prognostic factors were compared between the groups. A higher incidence of serosal invasion, lymph node metastasis and liver metastasis and poorer prognosis was observed in the AFP-positive group compared with the AFP-negative group (all p<0.05). Serum AFP showed the highest specificity (93.66%) and diagnostic accuracy (92.38%) for predicting liver metastasis among the 3 tumor markers examined. Multivariate survival analysis revealed that AFP positivity wa...Continue Reading

References

Jun 30, 1994·Biochemical and Biophysical Research Communications·T YamashitaN Kasai
Jan 1, 1956·Scandinavian Journal of Clinical and Laboratory Investigation·C G BERGSTRAND, B CZAR
Sep 30, 2006·Digestive Diseases and Sciences·Seok Reyol ChoiWaqar Qureshi
Feb 20, 2009·International Journal of Clinical Oncology·Seiji IsonishiTadao Tanaka
Nov 15, 2011·Journal of Gastric Cancer·Huan Chun, Sung Joon Kwon
Dec 17, 2011·The American Journal of Surgical Pathology·Tetsu KinjoTadakazu Shimoda
Apr 11, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hideaki ShimadaYutaka Takahashi
Oct 10, 2013·World Journal of Gastroenterology : WJG·Shoji HirajimaEigo Otsuji

❮ Previous
Next ❯

Citations

Apr 17, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yakun WangXiaotian Zhang
Apr 2, 2020·The Journal of International Medical Research·Xiang XuYugang Wu
Mar 5, 2020·Therapeutic Advances in Medical Oncology·Kecheng Zhang, Lin Chen

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.