High-Level PM2.5/PM10 Exposure Is Associated With Alterations in the Human Pharyngeal Microbiota Composition

Frontiers in Microbiology
Tian QinJianguo Xu

Abstract

Previous studies showed that high concentration of particulate matter (PM) 2.5 and PM10 carried a large number of bacterial and archaeal species, including pathogens and opportunistic pathogens. In this study, pharyngeal swabs from 83 subjects working in an open air farmer's market were sampled before and after exposure to smog with PM2.5 and PM10 levels up to 200 and 300 μg/m3, respectively. Their microbiota were investigated using high-throughput sequencing targeting the V3-V4 regions of the 16S rRNA gene. The genus level phylotypes was increased from 649 to 767 in the post-smog pharyngeal microbiota, of which 142 were new and detected only in the post-smog microbiota. The 142 new genera were traced to sources such as soil, marine, feces, sewage sludge, freshwater, hot springs, and saline lakes. The abundance of the genera Streptococcus, Haemophilus, Moraxella, and Staphylococcus increased in the post-smog pharyngeal microbiota. All six alpha diversity indices and principal component analysis showed that the taxonomic composition of the post-smog pharyngeal microbiota was significantly different to that of the pre-smog pharyngeal microbiota. Redundancy analysis showed that the influences of PM2.5/PM10 exposure and smoking on ...Continue Reading

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Citations

Nov 17, 2020·Frontiers in Microbiology·Yinhua WuXiaoyan Liu
Dec 15, 2020·Journal of Environmental Health Science & Engineering·Hossein KarimiYaghoub Hajizadeh
Sep 20, 2020·Toxicology Letters·Yanfeng XueXiangyang Kong
Jun 30, 2021·Environmental Science and Pollution Research International·Jin ZhuangQian Sun
Sep 10, 2021·Current Allergy and Asthma Reports·Evelyn M LelandMurugappan Ramanathan

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