High-level quinolone resistance is associated with the overexpression of smeVWX in Stenotrophomonas maltophilia clinical isolates

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Guillermo García-LeónMaría B Sánchez

Abstract

Stenotrophomonas maltophilia is the only known bacterium in which quinolone-resistant isolates do not present mutations in the genes encoding bacterial topoisomerases. The expression of the intrinsic quinolone resistance elements smeDEF, smeVWX and Smqnr was analysed in 31 clinical S. maltophilia isolates presenting a minimum inhibitory concentration (MIC) range to ciprofloxacin between 0.5 and > 32 μg/mL; 11 (35.5%) overexpressed smeDEF, 2 (6.5%) presenting the highest quinolone MICs overexpressed smeVWX and 1 (3.2%) overexpressed Smqnr. Both strains overexpressing smeVWX presented changes at the Gly266 position of SmeRv, the repressor of smeVWX. Changes at the same position were previously observed in in vitro selected S. maltophilia quinolone-resistant mutants, indicating this amino acid is highly relevant for the activity of SmeRv in repressing smeVWX expression. For the first time SmeVWX overexpression is associated with quinolone resistance of S. maltophilia clinical isolates.

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Citations

Aug 12, 2015·Annals of Intensive Care·Étienne RuppéFrançois Barbier
Sep 14, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Sara Hernando-AmadoJosé L Martínez
Nov 19, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chien-Jung PienMing-Li Liou
Apr 4, 2018·Antimicrobial Agents and Chemotherapy·María Blanca Sánchez, José Luis Martínez
Feb 23, 2017·Antimicrobial Agents and Chemotherapy·P BlancoJ L Martínez
Feb 14, 2020·Expert Review of Anti-infective Therapy·Teresa Gil-GilPaula Blanco
Aug 22, 2018·Antimicrobial Agents and Chemotherapy·P BlancoJ L Martínez
Aug 16, 2019·Clinical Microbiology Reviews·Joaquim Ruiz
Nov 4, 2020·Antimicrobial Agents and Chemotherapy·Punyawee DulyayangkulMatthew B Avison
Jan 20, 2018·Microbiology Spectrum·Yang WangCongming Wu
Jul 6, 2021·Frontiers in Pediatrics·Cecilia PerretJose A Castro-Rodriguez

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