PMID: 9526604Apr 4, 1998Paper

High levels of anticardiolipin antibodies in patients with abnormal embryo morphology who attended an in vitro fertilization program

American Journal of Reproductive Immunology : AJRI
F AzemJ B Lessing

Abstract

Recently, it has been suggested that anticardiolipin antibodies (ACAs) may serve as possible markers for reproductive failure. The association between ACAs and embryo morphology in patients undergoing in vitro fertilization (IVF) was investigated. This prospective study comprised 117 patients with either tubal factor or unexplained infertility. Embryo morphology was blindly scored from I to IV according to blastomere regularity and the presence of fragments. Anticardiolipin antibodies (immunoglobulin [Ig] G and IgM) were detected. Anticardiolipin antibodies were found in 26 (50%) of the 52 patients with abnormal morphology, compared with 13 (20%) of the 65 patients with normal embryo morphology (P = 0.001). No statistically significant differences were found between the prevalence of ACAs among patients with tubal factor and those with unexplained infertility (29.6% and 36.5%, respectively). Our study shows an association between embryo morphology and the presence of ACAs. This association may explain the low implantation rate and early pregnancy loss in patients with ACAs.

References

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Citations

Jan 30, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Lechoslaw PutowskiJerzy Jakowicki
Dec 10, 1999·American Journal of Reproductive Immunology : AJRI·E GevaA Amit
Jan 6, 2000·American Journal of Reproductive Immunology : AJRI·A S KaiderR G Roussev
May 14, 2014·Autoimmunity Reviews·Silvia D'IppolitoNicoletta Di Simone
Mar 1, 2006·Reumatología clinica·N Fernández-LlanioJ A Román-Ivorra
Feb 13, 2013·American Journal of Reproductive Immunology : AJRI·Shanmugam VelayuthaprabhuGovindaraju Archunan
Jul 19, 2011·American Journal of Reproductive Immunology : AJRI·Yi-Ping ZhongJing Li
Oct 21, 1999·Human Reproduction·B D KaiderR G Roussev
Feb 27, 2009·Journal of Reproductive Immunology·K L Buckingham, L W Chamley
Apr 26, 2006·American Journal of Reproductive Immunology : AJRI·Hidehiko MatsubayashiJohn A McIntyre
Sep 18, 2014·Lupus·C B Chighizola, G R de Jesus
Feb 22, 2012·American Journal of Reproductive Immunology : AJRI·Carolyn B Coulam, Brian Acacio
Dec 13, 2019·Lupus·G El HasbaniI Uthman
Jul 11, 2003·American Journal of Reproductive Immunology : AJRI·J A McIntyre
Jan 9, 2003·American Journal of Reproductive Immunology : AJRI·Carolyn B Coulam
Jul 18, 2009·Reproductive Medicine and Biology·Hidehiko Matsubayashi
Oct 6, 1998·Scandinavian Journal of Rheumatology. Supplement·Y Sherer, Y Shoenfeld
Jan 9, 2003·American Journal of Reproductive Immunology : AJRI·Carolyn B Coulam, Roumen Roussev
May 22, 2018·Obstetrics & Gynecology Science·Yeon Hee HongSeok Hyun Kim
Feb 11, 2020·Journal of Human Reproductive Sciences·Motahareh EhsaniMehdi Shahbazi

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