High levels of CD57+CD28- T-cells, low T-cell proliferation and preferential expansion of terminally differentiated CD4+ T-cells in HIV-elite controllers

Current HIV Research
Ezequiel Ruiz-MateosManuel Leal

Abstract

The study of clinical and demographic characteristics related to virus control and disease progression in patients who spontaneously control HIV vireamia (HIV-controllers) is of major interest. A particular cause of HIV control has not been found and the scenario could be partially explained by special homeostatic and immunological features. In this study, CD57+CD28- phenotype, T-cell activation and levels of proliferating T-cells in elite-controllers were studied in relation to spontaneous virus control. In HIV-controllers, 9% were AIDS-diagnosed and there was a high proportion of women. In elite-controllers, high T-cell CD57+CD28- phenotype and activation levels were found and, interestingly, there was a low proliferation of total and naïve T-cells and a high proliferation of the CD4+ T(EM)RA subset. Low T-cell proliferation and preferential expansion of terminally differentiated effector T-cell subsets could be an important factor for virus control in elite-controllers.

Citations

Jun 14, 2012·The Journal of Infectious Diseases·Lucie BarbluUNKNOWN ANRS EP36 HIV Controllers Study Group
Dec 12, 2012·The Journal of Infectious Diseases·Kawthar MachmachUNKNOWN HIV Controllers Consortium of the AIDS Spanish Network
Feb 10, 2012·Journal of Virology·K MachmachE Ruiz-Mateos
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Beatriz Dominguez-MolinaEzequiel Ruiz-Mateos
Mar 2, 2018·BMC Medicine·José M BenitoUNKNOWN ECRIS integrated in the Spanish AIDS Research Network

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