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High levels of circulating interleukin-4 and interleukin-10 in Kawasaki disease

International Archives of Allergy and Immunology

Feb 1, 1997

J HiraoT Ichimura

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Abstract

For analysis of the cytokine network in Kawasaki disease (KD), we measured over time the plasma levels of interferon (IFN)-gamma, interleukin (IL)-4 and IL-10 in patients with KD. Fifteen patients with KD were studied. Eight healthy children were selected as control subjects. Circulatin...read more

Mentioned in this Paper

Interleukins
Mucocutaneous Lymph Node Syndrome
IFNG
Recombinant Interleukin-10
Human leukocyte interferon
Interferon
Interleukin-10 Binding Activity
Human Interleukin-10 (Nonglycosylated)
Recombinant Interleukins
Interferons
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Interferon Signalling

Via interaction with their specific receptors, interferons (IFNs) activate signal transducer and activator of transcription (STAT) complexes. STAT activation initiates the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called IFN-stimulated response elements (ISREs) in the promoters of certain genes, known as IFN stimulated genes. Discover the latest research on interferon signalling here.

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High levels of circulating interleukin-4 and interleukin-10 in Kawasaki disease

International Archives of Allergy and Immunology

Feb 1, 1997

J HiraoT Ichimura

PMID: 9030095

DOI: 10.1159/000237447

Abstract

For analysis of the cytokine network in Kawasaki disease (KD), we measured over time the plasma levels of interferon (IFN)-gamma, interleukin (IL)-4 and IL-10 in patients with KD. Fifteen patients with KD were studied. Eight healthy children were selected as control subjects. Circulatin...read more

Mentioned in this Paper

Interleukins
Mucocutaneous Lymph Node Syndrome
IFNG
Recombinant Interleukin-10
Human leukocyte interferon
Interferon
Interleukin-10 Binding Activity
Human Interleukin-10 (Nonglycosylated)
Recombinant Interleukins
Interferons

Feeds With Similar Papers

Interferon Signalling

Via interaction with their specific receptors, interferons (IFNs) activate signal transducer and activator of transcription (STAT) complexes. STAT activation initiates the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called IFN-stimulated response elements (ISREs) in the promoters of certain genes, known as IFN stimulated genes. Discover the latest research on interferon signalling here.

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Paper Details
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  • Citations40
  • finger pointing at paper

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    We're still populating references for this paper, please check back later.
  • References
  • Citations40
1234

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