High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy

Cancer Biology & Therapy
Hajime OritaEdward Gabrielson

Abstract

Fatty acid synthase (FAS) is overexpressed in many human cancers and is considered to be a promising target for therapy. To investigate the expression of this candidate target in esophageal cancer, we evaluated expression of FAS protein in 22 cases of esophageal squamous cancer, 79 cases of esophageal adenocarcinoma and 16 cases of Barrett's esophagus with high-grade dysplasia--a lesion thought to represent a pre-invasive precursor to esophageal cancer. Using immunohistochemistry, we found significantly higher levels of FAS expression in 77% of the squamous cancers, 96% of the adenocarcinomas and 94% of the Barrett's lesions with high-grade dysplasia, when compared to levels in normal esophageal epithelium and non-dysplastic Barrett mucosa. To evaluate the potential for inhibiting this enzyme as a treatment of esophageal cancer, we treated mice bearing xenografts of the Colo680N esophageal squamous cell carcinoma cell line using C93, a rationally designed molecule that inhibits FAS activity. In these experiments, C93 significantly inhibited the growth of orthotopic xenograft tumors without causing anorexia and weight loss in the treated animals. We conclude that, similar to several other common types of human cancer, FAS is exp...Continue Reading

Citations

Aug 25, 2011·Biomarkers in Medicine·Yasuyuki KondoMasaru Yoshida
Jul 10, 2012·Indian Journal of Pathology & Microbiology·Zhi Li LiuYong Shu
May 17, 2015·Expert Review of Anticancer Therapy·Chao WangYu Wang
Mar 8, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Junjie ZhangChun Cai
Apr 5, 2018·Food & Function·Rachna Khosla SardanaAnil Panghal
Jun 23, 2012·Molecular Biology Reports·Yongli ZhouWeiguo Ma
Mar 6, 2015·World Journal of Gastroenterology : WJG·Kai YangChang-Zheng Wang
Feb 15, 2014·Oncology Letters·Tomoaki ItoYoshiaki Kajiyama
Aug 13, 2020·Mini Reviews in Medicinal Chemistry·Shailendra SinghN S Hari Narayana Moorthy
Aug 28, 2014·Journal of Proteome Research·Hai JinXianfu Gao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Hajime OritaEdward Gabrielson
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Rajeswari AnaparthyPrateek Sharma
© 2021 Meta ULC. All rights reserved