High levels of HIF-2alpha highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche

The Journal of Pathology
Alexander PietrasSven Påhlman

Abstract

High HIF-2alpha protein levels in the sympathetic nervous system-derived childhood tumour neuroblastoma as well as immature phenotype correlate to unfavourable outcome. Here we show that a small subset of perivascularly located, strongly HIF-2alpha-positive tumour cells (MYCN amplified) lacks expression of differentiation markers, but expresses neural crest and early sympathetic progenitor marker genes such as Notch-1, HES-1, c-Kit, dHAND, and vimentin. HIF-2alpha- and CD68-positive tumour-associated macrophages were frequently found close to the immature and HIF-2alpha-positive neuroblastoma cells and as VEGF levels are high in the perivascular niche, we hypothesize that neuroblastoma neural crest-like cells and macrophages cooperate to facilitate angiogenesis and thereby contribute to the aggressive neuroblastoma phenotype.

References

Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·M KanetaY Takahama
Mar 4, 2000·The Journal of Pathology·R D LeekA L Harris
Nov 2, 2001·Nature·T ReyaI L Weissman
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Annika JögiSven Påhlman
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
May 12, 2004·Biological Chemistry·Eric Metzen, Peter J Ratcliffe
Jun 2, 2004·Nature Reviews. Cancer·J Martin Brown, William R Wilson
Feb 21, 2006·Cancer Research·Max S WichaGabriela Dontu
Jan 16, 2007·Cancer Cell·Christopher CalabreseRichard J Gilbertson
Feb 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Annalisa PezzoloVito Pistoia

❮ Previous
Next ❯

Citations

Apr 22, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daniel BexellJohan Bengzon
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alexander PietrasSven Påhlman
May 17, 2011·Molecular Cancer Research : MCR·Qun LinZhong Yun
Jan 7, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jasper WoutersJoost J van den Oord
Dec 25, 2007·Biochemical and Biophysical Research Communications·Erik FredlundSven Påhlman
Aug 11, 2012·Expert Opinion on Therapeutic Targets·Bin BaoFazlul H Sarkar
Mar 2, 2012·Upsala Journal of Medical Sciences·Annika JögiSven Påhlman
Jan 22, 2011·Progress in Neurobiology·Helena L A VieiraAlessandro Vercelli
Oct 17, 2017·Cell and Tissue Research·Sven Påhlman, Sofie Mohlin
Dec 14, 2017·Proceedings of the National Academy of Sciences of the United States of America·Isabelle WesterlundJohan Holmberg
Dec 14, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sofie MohlinSven Påhlman
Jan 28, 2010·British Journal of Cancer·J M HeddlestonJ N Rich
Oct 9, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Cassandra M WeltenZia A Khan
Feb 5, 2019·Oncotarget·Kristoffer von StedingkDaniel Bexell
Aug 28, 2015·American Journal of Physiology. Cell Physiology·Muhammad Zaeem NomanSalem Chouaib
Sep 18, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Camilla U NiklassonSofie Mohlin
Jan 20, 2018·Nature Ecology & Evolution·Emma U HammarlundSven Påhlman
Dec 22, 2019·International Journal of Molecular Sciences·Carlos Huertas-CastañoFrancisco M Vega
Sep 29, 2020·Frontiers in Immunology·Kevin X Liu, Shweta Joshi
Nov 4, 2020·Neoplasia : an International Journal for Oncology Research·Elisa S GrassiAlexander Pietras
Oct 30, 2016·The American Journal of Pathology·Susana GalliJoanna Kitlinska
May 4, 2016·Pharmacology & Therapeutics·Caroline WigerupDaniel Bexell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.