High levels of human immunodeficiency virus infection of CD8 lymphocytes expressing CD4 in vivo

Journal of Virology
Alexandra CochraneP Simmonds

Abstract

Human immunodeficiency virus (HIV)-infected CD8 lymphocytes have been reported in vivo, but the mechanism of infection remains unclear. Experiments using the thy/hu mouse model support export of intrathymically infected CD8 precursors, while recent in vitro data suggest that mature CD8 lymphocytes upregulate CD4 upon activation (generating a CD8bright CD4dim phenotype) and are susceptible to HIV infection. To determine whether these mechanisms operate in vivo and to assess their relative importance in the generation of circulating HIV-infected CD8 lymphocytes, we quantified HIV long terminal repeat (LTR) DNA in CD8+ CD4- and CD8bright CD4dim lymphocytes isolated from HIV-infected individuals by fluorescence-activated cell sorting. HIV infection of CD8 lymphocytes was demonstrated in 17 of 19 subjects, with a significant inverse relationship between level of infection and CD4 lymphocyte count (R = -0.73; P < 0.001). The level of HIV infection of CD8bright CD4dim lymphocytes was significantly higher (median, 1,730 HIV LTR copies/10(6) cells; n = 9) than that of CD8+ CD4- lymphocytes (undetectable in seven of nine individuals; P < 0.01) and approached that of CD4 lymphocytes from the same individuals (median, 3,660 HIV LTR copies/...Continue Reading

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Citations

Sep 21, 2013·Viral Immunology·Sofia KourkountiChristina Antoniou
Oct 21, 2011·Journal of Virology·Anke HeigeleFrank Kirchhoff
Apr 19, 2005·Expert Opinion on Biological Therapy·L R Meireles-de-Souza, Robin J Shattock
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Apr 7, 2010·Journal of Biomedicine & Biotechnology·Anne AucherJulià Blanco
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Oct 4, 2019·Journal of Virology·Cosmo Z BuffaloXuefeng Ren
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Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sheila M KeatingAdrian V S Hill

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