High levels of human infection with Trypanosoma cruzi associated with the domestic density of infected vectors and hosts in a rural area of northeastern Argentina

Parasites & Vectors
Marta Victoria CardinalRicardo Esteban Gürtler

Abstract

Insecticide spraying campaigns designed to suppress the principal vectors of the Chagas disease usually lack an active surveillance system that copes with house reinvasion. Following an insecticide campaign with no subsequent surveillance over a 12-year period, we implemented a longitudinal intervention programme including periodic surveys for Triatoma infestans, full-coverage house spraying with insecticides, and selective control in a well-defined rural area of the Argentinean Chaco inhabited by Creoles and one indigenous group (Qom). Here, we conducted a cross-sectional study and report the age-specific seroprevalence of human T. cruzi infection by group, and examine the association between human infection, the onset of the intervention, the relative density of infected domestic bugs, and the household number of infected people, dogs, or cats. The seroprevalence of infection among 691 residents examined was 39.8% and increased steadily with age, reaching 53-70% in those older than 20 years. The mean annual force of infection was 2.5 per 100 person-years (95% CI: 1.8-3.3%). Infection in children younger than 16 years born before the intervention programme was two to four times higher in houses with infected T. infestans than ...Continue Reading

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Citations

Dec 17, 2019·PLoS Neglected Tropical Diseases·Maria Del Pilar FernándezRicardo E Gürtler
Jun 27, 2019·PLoS Neglected Tropical Diseases·Leonardo M LeonyFred L N Santos
Nov 30, 2019·Clinical Microbiology Reviews·Caryn BernJames H Maguire
May 13, 2021·PLoS Neglected Tropical Diseases·Marta Victoria CardinalRicardo Esteban Gürtler

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assays

Software Mentioned

Stata
STROBE
MuMIn
ResourceSelection
lme4
R

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