High levels of nucleolar expression of nucleolin are associated with better prognosis in patients with stage II pancreatic ductal adenocarcinoma.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Lan PengHuamin Wang

Abstract

Nucleolin is a major nucleolar protein that has been shown to be overexpressed in rapidly dividing cells and plays an essential role in cell proliferation and survival. However, the expression and significance of nucleolin in pancreatic ductal adenocarcinoma (PDA) have not been studied. We used a tissue microarray consisting of 1.0-mm cores of tumor and paired nonneoplastic pancreatic tissue from 69 pancreaticoduodenectomy specimens with stage II PDA. Nucleolin expression was evaluated by immunohistochemistry and scored quantitatively by image analysis. Nucleolin expression was classified as nucleolin-high or nucleolin-low using the median nucleolin labeling index of 3.5% as cutoff. Staining results were correlated with clinicopathologic features and survival. Both PDAs and PDA cell lines showed nucleolar staining for nucleolin. Nucleolin expression was higher in PDAs and PDA cell lines than in nonneoplastic ductal epithelial cells. Among the 69 stage II PDAs, 34 (49%) were nucleolin-high. The median overall survival was 65.2 +/- 16.3 months for patients who had nucleolin-high PDAs compared with 19.5 +/- 3.3 months for patients whose tumors were nucleolin-low (P = 0.03, log-rank method). No significant correlation between nucle...Continue Reading

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Citations

Sep 29, 2011·International Journal of Molecular Sciences·Meijuan ZongLiang Li
Jun 15, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Wensheng QiuLu Yue
May 30, 2015·Molecular Cancer·Bianca T HofmannGerrit Wolters-Eisfeld
Aug 10, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Junyuan YanLijun Chen
Jul 25, 2014·Journal of Cancer Therapy·Ka-To ShumJohn J Rossi
Feb 13, 2015·Journal of Virology·Pei-Yi SuChuan-Fa Chang
Apr 30, 2020·The Biochemical Journal·Gabrielle E CervoniRichard D Cummings
Jan 4, 2019·European Journal of Medicinal Chemistry·Hongtao Xu, Bo Liu

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