High levels of polo-like kinase 1 and phosphorylated translationally controlled tumor protein indicate poor prognosis in neuroblastomas

Journal of Neuro-oncology
Pramila RamaniChris Rogers

Abstract

Despite multimodality treatment, the long-term survival of high-risk patients with neuroblastomas is below 50%. New anti-mitotic drugs against targets, such as polo-like kinase 1 (PLK1), are being evaluated in early phase clinical trials. PLK1 phosphorylates the translationally controlled tumor protein (TCTP). We investigated the expression of PLK1 and the phosphorylated substrate, pTCTP, by immunostaining eighty-eight neuroblastomas. Digitally scanned slides were scored using image analysis software. The median PLK1 and pTCTP proliferation indices (PIs) were 4.6 and 1% respectively. There was moderate positive correlation between PLK1 and pTCTP (ρ = 0.65). The PIs for both markers were significantly higher in neuroblastomas from patients with adverse clinical (advanced-stage, high-risk group, primary abdominal compared to extra-abdominal sites), biological (MYCN amplification, 1p deletion, 17q gain) and pathological (undifferentiated or poorly differentiated status, high mitosis-karyorrhexis index, [MKI], unfavorable histology) factors. Using Cox regression models, higher-than-median PLK1 and pTCTP PIs were associated with a shorter overall survival (OS) and event-free survival (EFS) in the univariate analyses. In the multivar...Continue Reading

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Citations

Apr 22, 2017·Oncotarget·Mengyuan LiXiaosheng Wang
Jul 1, 2017·Pediatric Hematology and Oncology·Atif A AhmedMaxine Hetherington
Apr 8, 2020·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Eman H YousefLaila A Eissa
May 16, 2020·Seminars in Cell & Developmental Biology·Sonal Jaiswal, Priyanka Singh
Dec 2, 2020·Chemico-biological Interactions·Nicolas FischerThomas Efferth
Nov 13, 2020·BioMed Research International·Xiangyu ZhengHuan Luo
Sep 5, 2020·Journal of Drug Targeting·Ilma ShakeelMd Imtaiyaz Hassan

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