High levels of preoperative and postoperative N terminal B-type natriuretic propeptide influence mortality and cardiovascular complications after noncardiac surgery: A prospective cohort study

European Journal of Anaesthesiology
Carlos Álvarez ZurroRosa Méndez Hernández

Abstract

Major noncardiac surgery is associated with a 5% incidence of serious cardiovascular complications and with a 1 to 2% probability of death from cardiac causes. Over the last few decades, researchers have assessed the perioperative predictive power of several risk indices. Research is currently focused on the evaluation of biomarkers. The objective was to determine the incidence of high serum levels of N terminal B-type natriuretic propeptide (NT-proBNP) before and after surgery in adults undergoing elective major noncardiac procedures and to evaluate its relationship with mortality and cardiovascular complications occurring up to 30 days after surgery. Prospective cohort study. Enrolment was undertaken at a university hospital from October 2011 to July 2013. A total of 304 adults with cardiovascular risk factors who underwent noncardiac elective surgery. The relationship between preoperative and postoperative NT-proBNP serum levels and the emergence of cardiovascular complications, including all-cause mortality, during the first 30 days after surgery. The incidence of cardiovascular complications was 7.8% (n = 25), and the mortality rate was 4.3% (n = 13). Higher-than-normal NT-proBNP serum levels were found before surgery in 4...Continue Reading

References

Dec 25, 2007·Journal of the American College of Cardiology·Lori B Daniels, Alan S Maisel
Sep 2, 2008·European Journal of Heart Failure·Alan MaiselEugene Braunwald
Jul 16, 2009·Anesthesiology·Alisdair D S RydingDavid Burgess
Oct 17, 2009·Journal of the American College of Cardiology·Daniel BolligerMiodrag Filipovic
Jan 6, 2010·Annals of Internal Medicine·Meredith K FordDuminda N Wijeysundera
Jun 19, 2012·JAMA : the Journal of the American Medical Association·P J DevereauxSalim Yusuf
Sep 25, 2012·Lancet·Rupert M PearseUNKNOWN European Surgical Outcomes Study (EuSOS) group for the Trials groups of the European Society of Intensive Care Medicine and

❮ Previous
Next ❯

Citations

Mar 2, 2017·European Journal of Anaesthesiology·Michelle S Chew, Bernhard Walder
Dec 28, 2016·European Journal of Anaesthesiology·Carlos Álvarez ZurroRosa Méndez Hernández
Jul 7, 2017·European Journal of Anaesthesiology·Guy Haller, Bernhard Walder
Jul 10, 2018·Journal of the American Heart Association·Sai PolineniJeremiah R Brown
Nov 1, 2017·European Journal of Anaesthesiology·Sander W M Keet, Christa Boer
Jul 17, 2019·World Journal for Pediatric & Congenital Heart Surgery·Devin M ParkerJeremiah R Brown
Oct 8, 2020·European Journal of Anaesthesiology·Ancor Sanz-GarcíaLuis J Jimenez-Borreguero
Jul 7, 2021·Mayo Clinic Proceedings·Ravindra GaneshKaren F Mauck

❮ Previous
Next ❯

Software Mentioned

Stata

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.