High lib mRNA expression in breast carcinomas

DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes
Kazuki SatohHiroshi Yokota

Abstract

Lib, first identified as a novel beta-amyloid responsive gene in rat astrocytes, has an extracellular domain of 15 leucine-rich repeats (LRRs) followed by a transmembrane domain and a short cytoplasmic region. It is a distinctly inducible gene and is thought to play a key role in inflammatory states via the LRR extracellular motif, an ideal structural framework for protein-protein and protein-matrix interactions. To evaluate potential roles of Lib, we screened various tumors for Lib expression. Lib mRNA expression was high and uniquely expressed in breast tumor tissues, compared to paired normal breast tissues. Lib mRNA was localized in the ductal carcinoma cells and Lib protein displayed a homophilic association on the surface of cultured cells. These data suggest that Lib may play a role in the progression of breast carcinomas and may be a diagnostic marker for breast tumors.

Citations

Feb 19, 2016·Cell Cycle·Aaron L SarverAnindya Bagchi
Dec 31, 2008·Cancer Letters·Andreas KleinSusanne Seitz
Aug 16, 2005·Biochemical and Biophysical Research Communications·Kazuki SatohTatsuo Yamada
Jun 17, 2011·Advances in Dental Research·P R CooperA J Smith
Sep 28, 2017·BMC Systems Biology·Jing HeAndrea Califano
Sep 10, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Juncheng CuiZhenfeng Duan
May 17, 2018·Cancer Research·James W PurcellDebra T Chao

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