High loading of polygenic risk in cases with chronic schizophrenia

Molecular Psychiatry
Sandra Melanie MeierManuel Mattheisen

Abstract

Genomic risk profile scores (GRPSs) have been shown to predict case-control status of schizophrenia (SCZ), albeit with varying sensitivity and specificity. The extent to which this variability in prediction accuracy is related to differences in sampling strategies is unknown. Danish population-based registers and Neonatal Biobanks were used to identify two independent incident data sets (denoted target and replication) comprising together 1861 cases with SCZ and 1706 controls. A third data set was a German prevalent sample with diagnoses assigned to 1773 SCZ cases and 2161 controls based on clinical interviews. GRPSs were calculated based on the genome-wide association results from the largest SCZ meta-analysis yet conducted. As measures of genetic risk prediction, Nagelkerke pseudo-R(2) and variance explained on the liability scale were calculated. GRPS for SCZ showed positive correlations with the number of psychiatric admissions across all P-value thresholds in both the incident and prevalent samples. In permutation-based test, Nagelkerke pseudo-R(2) values derived from samples enriched for frequently admitted cases were found to be significantly higher than for the full data sets (Ptarget=0.017, Preplication=0.04). Oversamp...Continue Reading

References

Dec 1, 1984·Archives of General Psychiatry·P Cohen, J Cohen
Mar 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L H Lindström
May 17, 2000·American Journal of Medical Genetics·A G Cardno, I I Gottesman
Jul 29, 2004·Schizophrenia Bulletin·Martin KnappJudit Simon
Oct 1, 2005·Nordic Journal of Psychiatry·Klaus D JakobsenThomas Werge
Jul 26, 2006·Psychological Medicine·Paul LichtensteinPatrick F Sullivan
Jul 3, 2009·Nature·UNKNOWN International Schizophrenia ConsortiumPamela Sklar
Sep 30, 2009·Schizophrenia Research·Charlotte L AllanPeter McGuffin
Jul 3, 2010·The American Journal of Psychiatry·Sharon Schwartz, Ezra Susser
Sep 3, 2010·Psychological Medicine·S Schwartz, E Susser
Sep 14, 2010·Biological Psychiatry·Masashi IkedaNakao Iwata
Aug 4, 2011·Scandinavian Journal of Public Health·Carsten Bøcker Pedersen
Aug 4, 2011·Scandinavian Journal of Public Health·Elsebeth LyngeMatejka Rebolj
Aug 4, 2011·Scandinavian Journal of Public Health·Ole MorsPreben Bo Mortensen
Sep 20, 2011·Nature Genetics·UNKNOWN Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium
Jun 23, 2012·Journal of Psychiatric Research·Olalla CaseiroBenedicto Crespo-Facorro
Apr 5, 2013·PLoS Genetics·Frank Dudbridge
Jun 19, 2013·Nature Reviews. Genetics·Naomi R WrayPeter M Visscher
Aug 27, 2013·Nature Genetics·Stephan RipkePatrick F Sullivan
Dec 10, 2013·Annual Review of Clinical Psychology·Thomas Munk LaursenPreben Bo Mortensen
May 9, 2014·JAMA Psychiatry·Carsten Bøcker PedersenWilliam W Eaton
Jul 25, 2014·Nature·UNKNOWN Schizophrenia Working Group of the Psychiatric Genomics Consortium

❮ Previous
Next ❯

Citations

Feb 14, 2019·Der Nervenarzt·Markus M NöthenAndreas J Forstner
Dec 5, 2017·Psychological Medicine·Joanna MartinPaul Lichtenstein
Aug 29, 2019·Nature Neuroscience·Michael S BreenUNKNOWN CommonMind Consortium
Mar 27, 2018·Annual Review of Clinical Psychology·Ryan BogdanArpana Agrawal
May 31, 2017·Acta Psychiatrica Scandinavica·J-C DebostL Petersen
Dec 14, 2018·Nature Communications·Chun Chieh FanCarsten Bøcker Pedersen
Jun 26, 2020·Frontiers in Psychiatry·Sandra M MeierManuel Mattheisen
Nov 30, 2018·Frontiers in Psychiatry·Jaana SuvisaariTuukka T Raij
Apr 28, 2018·Nature Genetics·Naomi R WrayUNKNOWN Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Dec 14, 2018·Scientific Reports·Darryl W EylesJohn J McGrath
Aug 10, 2018·Translational Psychiatry·Hannah J JonesUNKNOWN 23 and Me Research Team
Mar 20, 2016·Schizophrenia Bulletin·Aiden Corvin, Patrick F Sullivan
Feb 9, 2021·Psychological Medicine·Sophie E LeggeKaarina Kowalec
Oct 15, 2020·JAMA Psychiatry·Graham K MurrayNaomi R Wray

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.