High lymphatic vessel density and presence of lymphovascular invasion both predict poor prognosis in breast cancer

BMC Cancer
Song ZhangLiguang Zou

Abstract

Lymphatic vessel density and lymphovascular invasion are commonly assessed to identify the clinicopathological outcomes in breast cancer. However, the prognostic values of them on patients' survival are still uncertain. Databases of PubMed, Embase, and Web of Science were searched from inception up to 30 June 2016. The hazard ratio with its 95% confidence interval was used to determine the prognostic effects of lymphatic vessel density and lymphovascular invasion on disease-free survival and overall survival in breast cancer. Nineteen studies, involving 4215 participants, were included in this study. With the combination of the results of lymphatic vessel density, the pooled hazard ratios and 95% confidence intervals were 2.02 (1.69-2.40) for disease-free survival and 2.88 (2.07-4.01) for overall survival, respectively. For lymphovascular invasion study, the pooled hazard ratios and 95% confidence intervals were 1.81 (1.57-2.08) for disease-free survival and 1.64 (1.43-1.87) for overall survival, respectively. In addition, 29.56% (827/2798) of participants presented with lymphovascular invasion in total. Our study demonstrates that lymphatic vessel density and lymphovascular invasion can predict poor prognosis in breast cancer....Continue Reading

References

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Citations

Jul 26, 2019·International Journal of Cancer. Journal International Du Cancer·Lothar C DieterichMichael Detmar
May 12, 2018·International Journal of Oncology·Adryan FristiohadyGeorg Krupitza
Aug 13, 2020·Journal of Surgical Oncology·Dana A DominguezAndrew M Blakely
Jun 3, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Gao GangDong Pin
Dec 7, 2019·Experimental and Molecular Pathology·Yanan ChangFen Mou

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