Jun 26, 2014

High manganese, a risk for Alzheimer's disease: high manganese induces amyloid-β related cognitive impairment

Journal of Alzheimer's Disease : JAD
Yawei TongDe-Hua Chui

Abstract

Excess manganese (Mn) in brain can be neurotoxic, implicated in several neurodegenerative disorders such as sporadic Alzheimer's disease (AD). However, little is known about the altered metal environment including elevated Mn in the progressive cognitive impairment of AD. Indeed, whether high Mn is associated with AD risk remains elusive. In the study, we recruited 40 Chinese elders with different cognitive statuses and investigated concentrations of Mn in whole blood and plasma amyloid-β (Aβ) peptides. Surprisingly, there were significant correlations of Mn with Mini-Mental State Examination score and Clinical Dementia Rating Scale score. In addition, plasma Aβ peptides increased with elevated Mn. Further studies both in vitro and in vivo demonstrated dose-related neurotoxicity and increase of Aβ by Mn treatment, which was probably caused by disrupted Aβ degradation. These data suggested that high Mn may be involved in the progress of AD as an essential pathogenic factor.

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Mentioned in this Paper

Mini-mental State Examination
Familial Alzheimer Disease (FAD)
Manganese
APP protein, human
Whole Blood
Pathogenic Organism
Presenilin-1
Curiosity
Brain
Neurodegenerative Disorders Pathway

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