High Maternal Circulating Cotinine During Pregnancy is Associated With Persistently Shorter Stature From Birth to Five Years in an Asian Cohort

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Sharon NgShiao-Yng Chan

Abstract

Self-reported maternal active smoking has been associated with reduced offspring birth length and shorter stature in early and late childhood. To use circulating cotinine as an objective biomarker to investigate the association between smoking and environmental tobacco smoke (ETS) exposure in pregnancy and longitudinal measures of offspring length/height from birth to 60 months. In 969 maternal-offspring dyads from the GUSTO cohort, maternal plasma cotinine at 26-28 weeks' gestation was measured by LC/MS/MS and categorized into four groups: Group 1: cotinine <0.17 ng/mL (the assay's detection limit) and no ETS exposure; Group 2: cotinine <0.17 ng/mL but self-reported ETS; Group 3: cotinine 0.17-13.99 ng/mL (ETS or light smoking); Group 4: cotinine ≥14 ng/mL (active smoking). Adjusting for infant sex, gestational age at birth, ethnicity, maternal age, education, parity, BMI, and height, Group 4 offspring were shorter at birth [z-score β = -0.42 SD units (SDs) (95% CI = -0.77 to -0.06)] than Group 1 offspring. Group 4 offspring continued to be shorter at older ages, with similar effect sizes at 3 months [-0.57 SDs (-0.95 to -0.20)], 36 months [-0.53 SDs (-0.92 to -0.15)], 48 months [-0.43 SDs (-0.81 to -0.04)], and 60 months [-0....Continue Reading

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Citations

May 21, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Anne H Y ChuShiao-Yng Chan
Dec 6, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Evelyn Xiu Ling LooElizabeth Huiwen Tham
Nov 5, 2020·International Journal of Environmental Research and Public Health·Martin M O'DonnellCatherine B Hayes
Jan 6, 2022·Addiction·Alys HavardJu Lee Oei

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